Browsing Honors College by Author "Fisher-Wellman, Kelsey H."
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Mitochondrial alterations accompany forced differentiation in acute myeloid leukemia.
Coalson, Hannah S. (East Carolina University, 2022-05-09)Leukemia is characterized by blocked hematopoietic differentiation. Blocked differentiation results in the uncontrolled proliferation of immature, malignant myeloblasts. To counteract myeloblast proliferation, forced ... -
Tissue-specific characterization of mitochondrial branchedchain keto acid oxidation using a multiplexed assay platform
Nguyen, Tiffany (East Carolina University, 2021-04-23)Alterations to branched-chain keto acid (BCKA) oxidation have been implicated in a wide variety of human diseases, ranging from diabetes to cancer. Although global shifts in BCKA metabolism-evident by gene transcription, ...