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    THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT

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    Author
    Alfhili, Mohammad Abdulmohsen
    Abstract
    Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the studies presented here, we provide an appraisal of TCS as a chemotherapeutic agent by investigating its influence on the growth and survival of lymphoma cells. We also examine the contribution of TCS to the development of anemia; a major side effect of chemotherapy with a prevalence as high as 90% in cancer patients. Finally, we identify nonionic detergents, often used as excipients in drug formulations, as potent inhibitors of TCS in vivo.
    URI
    http://hdl.handle.net/10342/7233
    Subject
     Cancer; Chemotherapy; Apoptosis 
    Date
    2019-05-07
    Citation:
    APA:
    Alfhili, Mohammad Abdulmohsen. (May 2019). THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT (Doctoral Dissertation, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/7233.)

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    MLA:
    Alfhili, Mohammad Abdulmohsen. THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT. Doctoral Dissertation. East Carolina University, May 2019. The Scholarship. http://hdl.handle.net/10342/7233. February 26, 2021.
    Chicago:
    Alfhili, Mohammad Abdulmohsen, “THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT” (Doctoral Dissertation., East Carolina University, May 2019).
    AMA:
    Alfhili, Mohammad Abdulmohsen. THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT [Doctoral Dissertation]. Greenville, NC: East Carolina University; May 2019.
    Collections
    • Biomedical Sciences
    • Dissertations
    Publisher
    East Carolina University

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