Browsing Health Sciences Campus by Type"Master's Thesis"
Now showing items 101-120 of 131
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Speech Production Analyses: Characterizing Typical Development versus Childhood Apraxia of Speech
(East Carolina University, 2010)Childhood Apraxia of Speech (CAS) is a controversial diagnosis that is frequently based on clinical perceptions, with treatment success based on the same perceptual measures. Because additional, less abstract diagnostic ... -
SPINAL CORD REFLEXES IN A BRAIN-IRON DEFICIENT MODEL OF RESTLESS LEGS SYNDROME: ROLE OF DOPAMINE AND ADENOSINE RECEPTORS
(East Carolina University, 2021-05-04)Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely disrupts sleep. RLS patients regularly present with a condition known as Brain Iron Deficiency (BID), and BID is commonly associated with altered dopamine ... -
Stability of conversational language samples from children in kindergarten: the effects of time, sample length, and topic
(East Carolina University, 2010)The purpose of this study was to examine the reliability of measures from conversational language samples in the school-aged population. Two 10-minute conversational language samples were collected from 20 at-risk kindergarten ... -
Structural and functional analysis of the Vaccinia virus O1 virulence protein
(East Carolina University, 2017-07-26)Poxviruses are double-stranded DNA viruses capable of causing disfiguring and deadly disease in a wide range of hosts, from insects to mammals. Orthopoxviruses (OPXV) encode many proteins that are not essential for viral ... -
Subjective and objective screening measures for dysphonia pre-thyroidectomy
(East Carolina University, 2013)There has been a link established between post-surgical dysphonia and thyroidectomy procedures and various studies identify that a large percentage of these patients have dysphonia after surgery. Most of these incidences ... -
Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
(East Carolina University, 2017-07-19)Alzheimer's disease (AD) is a progressive disease characterized by cognitive decline and memory loss. Memory loss observed in AD results from the loss of neurons and synapses which may be caused by the disruption of the ... -
Temporal stability of the electronic version of the Motor-Free Visual Perception Test third edition (MVPT-3)
(East Carolina University, 2014)In today's technology based society, children are learning information from digital devices and are currently being tested by paper assessments. New electronic assessments have been created to try to compensate for this ... -
TGF-β Signaling, Via Smad3, Mediates Notch Pathway-Induced Stemness and Epithelial to Mesenchymal Transition in Colon Cancer Cells
(East Carolina University, 2017-08-21)Late stage colorectal cancer (CRC) remains a challenging disease to treat due to several factors including stemness and epithelial to mesenchymal transition (EMT). Dysfunctional signaling pathways in CRC contribute to these ... -
The Assessment of Muscle Oxygen Saturation in Students During Maximal VO2 Exercise and High Intensity Intervals
(East Carolina University, 2017-04-28)The advancement of human performance benefits from state-of-the-art technology to improve the ability to monitor and evaluate physiological adaptations in athletes. Previously validated as a reliable tool for measuring ... -
The Circadian Rhythm and its Role in the Dynamic Dopamine Neuron Phenotype
(East Carolina University, 2021-05-04)The circadian rhythm is strongly implicated in many neuropsychiatric and neurodegenerative disorders, all of which are associated with altered dopamine (DA) neurotransmission in the substantia nigra and ventral tegmental ... -
The Effectiveness of Interactive Metronome® as a Tool to Improve Cognition and Motor Performance in Healthy Older Adults in Eastern North Carolina
(East Carolina University, 2016-12-15)The purpose of this study was to measure the effectiveness of the Interactive Metronome (IM) in improving cognitive and motor performance in healthy older adults. As the aging adult population continues to rise, it is ... -
THE EFFECTIVENESS OF USING AN INTERACTIVE DRIVING SIMULATOR TO IMPROVE DRIVING SKILLS AND ABILITIES FOR TEENS AND YOUNG ADULTS WITH AUTISM SPECTRUM DISORDER WITHIN THE CONTEXT OF A DRIVING BOOTCAMP
(East Carolina University, 2016-12-15)Purpose: The purpose of this study was to determine the effectiveness of the interactive driving simulator as an intervention tool for teens and young adults with Autism Spectrum Disorder. Method: A pretest/post-test ... -
The Effectiveness of Visual Scanning Training to Improve Functional Performance Poststroke: A Case Study in Eastern North Carolina
(East Carolina University, 2018-06-18)Rationale: Although an abundance of research exists regarding overall rehabilitation interventions poststroke, there is a lack of evidence for treatment of visual deficits. Additionally, eye tracking glasses may be used ... -
The Influence of Language Phenotype on Predictors of Emergent Literacy in Children with an Autism Spectrum Disorder
(East Carolina University, 2018-05-01)The development of emergent literacy skills in children with Autism Spectrum Disorders (ASD) is a growing subject of inquiry in the field of communication sciences and disorders; however, few studies have investigated the ... -
The Role of the Notch-3 Receptor in Stemness, EMT, and Tumorigenesis in Colorectal Cancer
(East Carolina University, 2016-05-05)As the second leading cause of cancer death worldwide, colorectal cancer (CRC) poses a significant threat to both men and women alike. Although a small percentage of CRC cases are inherited, the majority of cases arise ... -
TMEFF2 is an epigenetic modulator that promotes androgen independent growth in castration-resistant prostate cancer cells
(East Carolina University, 2014)While the ability to detect PCa has improved significantly due to PSA screenings, the survival rate for men diagnosed with PCa has remained stagnant, and the disease remains the second leading cause of cancer related deaths ... -
Understanding the Molecular Mechanisms that Contribute to Parkinson’s Disease: Defining the Role of Ca2+ in TG2: α-synuclein Macromolecular Complex Assembly
(East Carolina University, 2018-12-10)Transglutaminase 2 (TG2) is an allosteric enzyme ubiquitously expressed in human tissue. This versatile enzyme has both Ca2+ -dependent, transamidase and GTPase activities. TG2's Ca2+ -dependent transamidase activity is ... -
The use of a personal fitness device in conjunction with online social networking as an effective delivery system for occupational therapy community practice to enhance an individual's personal occupation and self-efficacy
(East Carolina University, 2011)Participants wore a pedometer tracking device "fitbit" and participated in an on-line social support group daily. Data was collected through the "fitbit" including steps taken and distance traveled. Participants completed ...