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Now showing items 1792-1811 of 2643
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Osteopontin is not Critical for Otoconia Formation or Balance Function
(East Carolina University, 2008-06)Unlike the structural and mechanical role of bone crystals, the inertial mass of otoconia crystals provides a shearing force to stimulate the mechanoreceptors of the utricle and saccule (the gravity receptor organ)under ... -
Otoconin-90 Deletion Leads to Imbalance but Normal Hearing: A Comparison with Other Otoconia Mutants
(East Carolina University, 2008-04)Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ). We recently showed that otoconin-90 ... -
Outcomes of Roux-en-Y gastric bypass surgery for severely obese patients with type 1 diabetes: a case series report
(2010)Roux-en-Y gastric bypass surgery (RYGB) reverses type 2 diabetes (DM2) in approximately 83% of patients with morbid or severe obesity. This procedure has been performed in small numbers of severely obese patients with type ... -
Outpatient Colonoscopy by Rural Family Physicians
(East Carolina University, 2005-03)PURPOSE Five percent of family physicians offer colonoscopy services, either in the office or the hospital, often in rural areas that have no gastroenterologist. Two previous large series have shown the quality and safety ... -
Overcoming resistance to molecularly targeted anticancer therapies: rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies
(East Carolina University, 2007-06)Accumulating evidence suggests that cancer can be envisioned as a "signaling disease", in which alterations in the cellular genome affect the expression and/or function of oncogenes and tumour suppressor genes. This ... -
Oxidative stress response in an anaerobe, Bacteroides fragilis: a role for catalase in protection against hydrogen peroxide.
(East Carolina University, 1996-12)Survival of Bacteroides fragilis in the presence of oxygen was dependent on the ability of bacteria to synthesize new proteins, as determined by the inhibition of protein synthesis after oxygen exposure. The B. fragilis ... -
Oxytocin Modulation of Zebra Finch Vocal Development
(East Carolina University, 2010)Autism spectrum disorder is associated with deficits in three main behavioral areas: social behaviors, repetitive behaviors, and language abnormalities. Accumulating evidence suggests a potential role for oxytocin signaling ... -
OZONE-INDUCED ALTERATIONS IN MACROPHAGE FUNCTION AND THE PROTECTIVE ROLE OF SR-BI
(East Carolina University, 2020-06-22)Ozone (O3), a criteria air pollutant, is the primary component of photochemical smog. Currently, over 140 million people in the United States are exposed to levels of O3 deemed unhealthy by the Environmental Protection ... -
p53 and NGAL: dual regulatory roles in advanced prostate cancer
(East Carolina University, 2011)The development of prostate cancer from small regions of hyperplasia to invasive tumors requires genetic and epigenetic alterations of critical cellular components to aid in the development of cells more adapted for aberrant ... -
A Pacific Food Guide from the Children's Healthy Living PRogram
(2016-02)The paper describes the development of the Pacific Food Guide. The Food Guide includes fruits, vegetables, fish and animals not typically found in the US Food Guides but are consumed by individuals living int the Pacific. ... -
Pain coping skills training for African Americans with osteoarthritis (STAART): study protocol of a randomized controlled trial
(2016-08-23)Background: African Americans bear a disproportionate burden of osteoarthritis (OA), with higher prevalence rates, more severe pain, and more functional limitations. One key barrier to addressing these disparities has been ... -
Pain Management after Cardiac Surgery
(East Carolina University, 2009)Postoperative pain relief is one of the most important concerns for patients undergoing cardiac surgery and is one of the most clinically challenging problems for nurses. It is widely recognized that postoperative pain can ... -
PAIN SUPPORT FROM FAMILY AND PROVIDERS IN THE DIABETIC AMPUTEE: A LIVED EXPERIENCE
(East Carolina University, 2018-05-03)Chronic pain after lower extremity amputation surgery has been reported in up to 80% of patients. Amputations, which are among the most debilitating chronic complication of diabetes have a variety of consequences including ...