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Perioperative Corneal Abrasion: An Exploration of Certified Registered Nurse Anesthetists’ Preferences for Corneal Abrasion Prevention
(2022-11-23)Corneal abrasions are the most common eye injury occurring during the perioperative period and anesthesia providers are responsible for maintaining patient safety during this time. This quality improvement project was ... -
Perioperative Corneal Abrasion: An Exploration of Certified Registered Nurse Anesthetists’ Preferences for Corneal Abrasion Prevention
(2022-11-23)Corneal abrasions are the most common ophthalmic complication that occur during general anesthesia, resulting in 2-3% of anesthesia malpractice suits. However, no studies were found in current literature that addressed ... -
Perioperative ECG Lead Placement
(2023-11-22)Patients in the perioperative setting are susceptible to incorrect ECG lead placement due to a variety of obstacles such as chest tubes and bandages, as well as surgical sites and positions. Inaccurate and/or inconsistent ... -
Perioperative Management of Postoperative Nausea and Vomiting: A Quality Improvement Project
(2023-12-06)Postoperative nausea and vomiting (PONV) is an adverse event affecting 30% of the general surgical population and up to 80% of high risk patients. In addition to being distressing to patients, PONV is also associated with ... -
Perioperative Temperature Monitoring and Management to Maximize Patient Safety: A Quality Improvement Project
(2022-11-23)Appropriate temperature monitoring and management is an important part in optimizing patient success in the operative theatre. Perioperative hypothermia remains a threat to patient morbidity and mortality and consistent ... -
Peripheral Arterial Disease and Risk of Atrial Fibrillation and Stroke: The Multi�Ethnic Study of Atherosclerosis
(2014-12)Background Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for ... -
Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
(East Carolina University, 2019-07-03)Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ... -
Peroxisome Proliferator-Activated Receptor-γ Regulates the Expression of Alveolar Macrophage Macrophage Colony- Stimulating Factor
(East Carolina University, 2008-07-01)Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) and in the GMCSF knockout mouse, a murine ... -
Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression
(2013)There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone ... -
A Perspective on Systemic Nutrition and Nutritional Genomics
(East Carolina University, 2009)The brain and the gut work synergistically with each other and other organs. Reviewing nutrition systemically (rather than by single organs) is a holistic way for dietitians to evaluate their clients’ health status. ... -
Pet Therapy and Resilience
(2023-07-21)Nurses are consistently in high-stress working conditions and exposed to direct insults caring for the critically ill. Nurse-related stress and burnout threaten nurses’ mental well-being and contribute to turnover. Workload ... -
Pharmaceutically acceptable fixed-dried human blood platelets
(1999-11-30)Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution; adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change ... -
Pharmacological Regulation of Neural Circuit Formation in hIPSC-Derived Neurons and ‘Mini-Brains’
(East Carolina University, 2018-07-20)Emerging evidence suggests that altered neural connectivity, particularly at the level of synaptic connections, contributes to the pathology of many neurodevelopmental and neurodegenerative diseases. For instance, post-mortem ... -
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
(East Carolina University, 1995-10)Protein kinase C (PKC) modulates growth, differentiation, and apoptosis in a cell-specific fashion. Overexpression of PKC-a in MCF-7 breast cancer cells (MCF-7-PKC-a cell) leads to expression of a more transformed phenotype. ... -
The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
(2010-06)The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under physiological conditions. However, aberrant PI3K/Akt/mTOR ... -
Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells
(2012-02)BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ...