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Now showing items 2437-2456 of 2641
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The Endocannabinoid System Regulates Synaptogenesis in a Cortical Spheroid Model of Fetal Neurodevelopment
(East Carolina University, 2021-07-20)The endocannabinoid system plays a complex role in synaptogenesis and the subsequent development of neural circuitry during fetal brain development. The cannabinoid receptor type 1 controls synaptic strength at both ... -
THE HYALURONAN EXTRACELLULAR MATRIX CRITICALLY REGULATES SYNAPSE FORMATION IN DEVELOPING NEURAL NETWORKS
(East Carolina University, 2021-04-21)The majority of neurodevelopmental disorders present with an imbalance in synaptic signal transmission. The delicate balance of excitatory to inhibitory synaptic transmission is regulated by multiple extracellular and ... -
The Impact of COVID-19 on the Work System's Influence on Care Processes and Ambulation Outcomes
(East Carolina University, 2022-07-15)Ambulation is one of the most frequently reported missed nursing care activities for hospitalized patients. The COVID-19 pandemic forced hospitals to make systems changes to minimize transmission of the disease and compromised ... -
The Impact of COVID-19 on the Work System's Influence on Care Processes and Ambulation Outcomes
(East Carolina University, 2022-07-15)Ambulation is one of the most frequently reported missed nursing care activities for hospitalized patients. The COVID-19 pandemic forced hospitals to make systems changes to minimize transmission of the disease and compromised ... -
The Influence of Diet-Induced Obesity and N-3 Fatty Acids on the Cardiac Mitochondrial Phospholipidome and Respiratory Activity
(East Carolina University, 2017-08-16)Cardiac mitochondrial phospholipids, notably cardiolipin (CL), regulate inner mitochondrial membrane (IMM) organization and protein function, particularly the enzymes associated with respiration. In a range of metabolic ... -
The Influence of Language Phenotype on Predictors of Emergent Literacy in Children with an Autism Spectrum Disorder
(East Carolina University, 2018-05-01)The development of emergent literacy skills in children with Autism Spectrum Disorders (ASD) is a growing subject of inquiry in the field of communication sciences and disorders; however, few studies have investigated the ... -
The Influence of Orthodontic Appliances on Magnetic Resonance Imaging of the Velopharynx
(East Carolina University, 2022-12-08)Magnetic resonance imaging (MRI) is becoming increasingly valuable among cleft palate craniofacial teams in patients with velopharyngeal insufficiency (VPI). One hindrance to the growing use of MRI among the cleft population ... -
The Integrated 50-Minute Hour: Person-Centered Counseling and Heart Rate Variability Biofeedback Training
(East Carolina University, 2016-12-13)The field of mental health has moved toward new approaches for the improvement of treatment through the application of knowledge regarding human anatomy and mental health symptomology. Mental health research and education ... -
The Lived Experience of Nursing Staff in Skilled Nursing Facilities: Identification of Urinary Tract Infection in Residents
(East Carolina University, 2022-12-01)Annually, 50-70% of skilled nursing facility (SNF) residents receive at least one antibiotic, with up to 75% of those prescribed inappropriately. One-third of the antibiotic prescriptions are ordered to treat urinary tract ... -
The M2a macrophage phenotype accompanies pulmonary granuloma resolution in Mmp12 knock-out mice instilled with multiwall carbon nanotubes
(MDPI, 2021-10-13)Sarcoidosis is a chronic disease with unknown etiology and pathophysiology, characterized by granuloma formation. Matrix Metalloproteinase-12 (MMP12) is an elastase implicated in active granulomatous sarcoidosis. Previously, ... -
THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION
(East Carolina University, 2019-07-26)Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying ... -
THE PRO-INFLAMMATORY ROLE OF G-PROTEIN COUPLED RECEPTOR 4 IN AN ACIDIC MICROENVIRONMENT
(East Carolina University, 2018-07-20)The endothelium of the microvascular system serves an ideal mediator between circulating blood and tissues in order to regulate systemic homeostasis. During vascular disease, the normal function and phenotype of endothelial ... -
The Psychosocial Implications of Being Lesbian, Gay, and Bisexual Military Personnel in a Post Don't Ask, Don't Tell Era
(East Carolina University, 2018-04-24)Scholarly research on sexual minority military personnel was silenced until the United States (U.S.) Congress passed the Don't Ask, Don't Tell (DADT) Repeal Act of 2010. Not only did the repeal liberate lesbian, gay, and ...