Browsing Health Sciences Campus by Title
Now showing items 676-695 of 1097
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Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
(2014-01)Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated ... -
Multilevel Discourse Processing Analyses in Adults with a Cognitive Impairment
(East Carolina University, 2016-12-13)Participants with a cognitive impairment associated with Alzheimer's disease (AD) present with discourse impairments early within the disorder. These discourse impairment are associated with declines in episodic, semantic, ... -
Multiple Kinase Involvement in the Regulation of Vascular Growth
(New York: InTech Open Access Publishers, 2012-06)The initial discovery of protein phosphorylation as a regulatory mechanism for the control of glycogen metabolism has led to intense interest of protein phosphorylation in regulating protein function (Cohen et al., 2001). ... -
Multiple Translation Factor eIF4G (IFG-1) Isoforms are Required for the Apoptosome-Dependent Activation of Germ Cell Apoptosis
(East Carolina University, 2010)Apoptosis is a naturally occurring process during animal development required for the programmed killing and removal of injured cells. Cellular insult induces a switch in translation that allows for the rapid synthesis ... -
MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
(2014-06)MuRF1 is a previously reported ubiquitin-ligase found in striated muscle that targets troponin I and myosin heavy chain for degradation. While MuRF1 has been reported to interact with mitochondrial substrates in yeast ... -
Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer
(2016-03)Background Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote tumor development and to be a good target for cancer treatment. Most studies to date have used human mesothelin ... -
Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis
(2015-01)Background Maintenance of T cell immune homeostasis is critical for adequate anti-tumor immunity. The transcription factor Ikaros is essential for lymphocyte development including T cells. Alterations in Ikaros expression ... -
Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment
(2015-05)Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role ... -
Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
(2012-09)The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, ... -
N-3 polyunsaturated fatty acids differentially enhance B-cell mediated immunity in lean and obese mice
(East Carolina University, 2014)Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are bioactive n-3 polyunsaturated fatty acids (PUFAs) in fish oil that exert immunomodulatory effects. The general paradigm suggests n-3 PUFAs exert immunosuppressive ... -
Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma
(2012-08)NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant ... -
The Need for Interprofessional Collaborative Ready Nutrition and Dietetics Practitioners
(2014-10-01)This is the full length paper of what turned out to be a published brief after going through peer review. Many of our colleagues have requested the original full length description which is more of a call to action for ... -
Negative Charges at Protein Kinase C Sites of Troponin I Stabilize the Inactive State of Actin
(East Carolina University, 2008-01-15)Alterations in the troponin complex can lead to increases or decreases in contractile activity. Most mutations of troponin that cause hypertrophic cardiomyopathy increase the activity of cardiac muscle fibers. In at least ... -
Negative sexual experiences and rape: understanding the relationship between adult and childhood sexual victimization and somatic complaints, psychological factors, and self-rated health in college women
(East Carolina University, 2014)Sexual Victimization is a major issue in our society. The results of sexual victimization can persist throughout life and can be debilitating. Sexual victimization affects mental, sexual, and physical health. College women ... -
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
(2011)Background Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease ... -
Neurogenic inflammation and sensitivity to environmental chemicals.
(East Carolina University, 1993-08)Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. ... -
Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity.
(East Carolina University, 1995-01)Neurogenic switching is proposed as a hypothesis for a mechanism by which a stimulus at one site can lead to inflammation at a distant site. Neurogenic inflammation occurs when substance P and other neuropeptides released ... -
Neuropeptide Y analogues, compositions and methods of lowering blood pressure
(2000-06-13)Neuropeptide Y analogues, and their compositions are effective for lower blood pressure. -
New nurse transitions: a qualitative study of perceived difficulties
(East Carolina University, 2013)The transition from student to registered nurse has proven difficult for new graduate nurses. While organizations have implemented structures and processes to support new nurse transition into practice, new nurse turnover ... -
Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates
(2010)Nocturnal bronchoconstriction is a common symptom of asthma in humans, but is poorly documented in animal models. Thoracoabdominal asynchrony (TAA) is a noninvasive clinical indication of airway obstruction. In this study, ...