Browsing Health Sciences Campus by Author "Alleman, Rick J."
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The “Goldilocks Zone� from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle
Alleman, Rick J.; Katunga, Lalage Adalaide; Nelson, Margaret A. M.; Brown, David A.; Anderson, Ethan (2014-09)Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ... -
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
Alleman, Rick J. (East Carolina University, 2016-05-03)Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ... -
Exercise-Induced Protection Against Reperfusion Arrhythmia Involves Stabilization of Mitochondrial Energetics
Spangenburg, Espen; Alleman, Rick J.; Tsang, Alvin M.; Ryan, Terence E.; Patteson, Daniel J.; McClung, Joseph M.; Shaikh, Saame Raza; Neufer, P. Darrell; Brown, David A. (2016-05-15) -
Mitochondrial Therapy Improves Limb Perfusion and Myopathy Following Hindlimb Ischemia
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Alleman, Rick J.; Tsang, Alvin M.; Green, Thomas D.; Neufer, P. Darrell; Brown, David A. (2016-08-01) -
Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?
Alleman, Rick J.; Stewart, Luke M.; Tsang, Alvin M.; Brown, David A. (2015-05)Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that ...