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An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
(East Carolina University, 1988-08)
We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on glucose transport. ...
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
(East Carolina University, 1987-10)
We have tested the hypothesis that in vitro exposure of insulin-
resistant adipocytes with insulin results in improved insulin
action. A primary culture system of adipocytes from obese
subjects with ...
Bariatric Surgery: Risks and Rewards
(East Carolina University, 2008-11)
Context: Over 23 million Americans are afflicted with severe obesity, i.e. their body mass index (in
kilograms per square meter) values exceed 35. Of even greater concern is the association of the
adiposity with comorbidities ...
Diabetes: The Evolution of a New Paradigm
(East Carolina University, 2004-01)
Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.
(East Carolina University, 1988-04)
Insulin-like growth factor-I (IGF-I) in human hepatoma cells
(HEP-G2) has, in addition to its effect on cell growth, shortterm
metabolic effects acting through its own receptor. We
have demonstrated that normal ...
Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus.
(East Carolina University, 1995-09)
OBJECTIVE: This report documents that the gastric bypass operation provides long-term control for obesity and diabetes. SUMMARY BACKGROUND DATA: Obesity and diabetes, both notoriously resistant to medical therapy, continue ...
Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor.
(East Carolina University, 1994-06-15)
Although the growth-promoting effects of insulin-like growth factor II (IGF-II) have been intensively studied, the acute actions of this hormone on glucose metabolism have been less well evaluated, especially in skeletal ...
Thoracic neuroblastoma presenting as a cystic hygroma.
(East Carolina University, 1988-10)
A case of thoracic neuroblastoma with extension into the supraclavicular fossa is described. By physical examination and ultrasound the patient was thought to have a cystic hygroma with mediastinal extension. A 'cystic' ...
Gastrogastric fistulas. A complication of divided gastric bypass surgery.
(East Carolina University, 1995-04)
Objective
This report warns that gastrogastric fistulas may follow the division of the stomach in bariatric surgery.
Summary Background Data
Although surgery is the most effective therapy for morbid obesity, the ...
Is type II diabetes mellitus (NIDDM) a surgical disease?
(East Carolina University, 1992-06)
Since February 1, 1980, 515 morbidly obese patients have undergone
the Greenville gastric bypass (GGB) operation. Of these,
212 (41.2%) were euglycemic, 288 (55.9%) were either diabetic
or had glucose intolerance, and ...