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Now showing items 1061-1070 of 2687
A SINGLE-CHAIN GMCSF-MOG TOLEROGENIC VACCINE EXPANDS MOG-SPECIFIC CD25+ FOXP3+ REGULATORY T CELLS THROUGH LOW-EFFICIENCY ANTIGEN RECOGNITION EVENTS TO INHIBIT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2019-12)
Previous studies showed that tolerogenic vaccines comprised of single-chain GMCSF-neuroantigen (NAg) fusion proteins inhibited experimental autoimmune encephalomyelitis (EAE) in rodents. The studies detailed here provide ...
DEVELOPMENT OF SMALL-MODELCULE INHIGITORS OF THE INTIATING PROTEASES, C1r AND C1s, OF THE CLASSICAL COMPLEMENT PATHWAY
(2019-12)
Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ...
MOLECULAR MECHANISM OF THE CYTOTOXIC AND IMMUNOSTIMULATORY ACTIVITY OF 15 DEOXY PROSTAMIDE J2: INVESTIGATION OF CHOP10 AND NFĸB SIGNALING IN COLON CANCER
(East Carolina University, 2019-08-13)
The endoplasmic reticulum (ER) stress pathway is a prominent regulator of cancer cell death and as a result, ER stress inducers are being exploited pharmacologically. Cytotoxic ER stress is typically regulated by the ...
Employee Satisfaction with Onsite Clinic and Collaborative Care Pharmacy
(2019-10-15)
Background: On-job-productivity loss (presenteeism), voluntary non-attendance at work (absenteeism), work-related injuries, and the wage replacement cost of disability are major factors promoting the need for employer-based ...
FUNCTIONS OF CLAUDIN-7 IN THE SELF-RENEWAL OF INTESTINAL EPITHELIUM
(East Carolina University, 8/5/2020)
Tight junctions (TJ) are located at the most apical region of the junctional complex and contain many integral membrane proteins. Claudin 7 (Cldn7) is a TJ membrane protein located at the apical TJ and basolateral side of ...
The Medical Library as a Component of a Medical School Outreach Experience
(2020-01)
The US is facing a shortage of physicians for minorities and patients in disadvantaged areas. Many medical schools have pipeline programs to promote the interest of minority students in medicine. The Brody School of ...
MEASUREMENT OF WORD RETRIEVAL IN THE DISCOURSE OF PERSONS WITH APHASIA: STANDARD CORE LEXICON ITEM DEVELOPMENT AND PSYCHOMETRIC PROPERTIES
(East Carolina University, 8/5/2020)
Core lexicon measures are a quantitative measure of lexical use in discourse for persons with aphasia. It is intended to provide clinicians with a clinician-friendly means to quantify lexical use in discourse based on ...
METHODS OF IDENTIFYING NEUROLOGICAL DELIRIUM (MIND) STUDY
(East Carolina University, 8/5/2020)
Delirium is a major concern for critically ill older patients because it is associated with significant risk to quality of life and mortality. The United States spends approximately $164 billion in Medicare funding annually ...
Eastern North Carolina and the 1918 Influenza Epidemic
(2019-10-28)
As the Great War came to an end in the fall of 1918, a lethal disease spread across the globe. By the time the epidemic concluded in March 1919, more people died from the “Spanish” Influenza than died in the war, including ...
Multi-spectral physiologic visualization (MSPV) using laser imaging methods and systems for blood flow and perfusion imaging and quantification in an endoscopic design
(2017-08-28)
Multispectral imaging systems are provided including a first light source having a first wavelength configured to image a sample; a second light source, different from the first light source, having a second wavelength, ...