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Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
(2016-03)
Background
Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and ...
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon
(2012-03)
Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to ...
PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors
(2015-04)
Class I phosphatidylinositol 3-kinases (PI3Ks) are frequently activated in T-cell acute lymphoblastic leukemia (T-ALL), mainly due to the loss of PTEN function. Therefore, targeting PI3Ks is a promising innovative approach ...
Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood
(2015-05)
Murine embryonic stem (ES) cells can differentiate in vitro into three germ layers (endodermic, mesodermic, ectodermic). Studies on the differentiation of these cells to specific early differentiation stages has been aided ...
The Impact of Mild Stroke on Participation in Physical Fitness Activities
(2012)
Objective. To compare participation in moderate to high intensity physical activities in persons before and after a mild stroke. Methods. We used data from the Cognitive Rehabilitation and Research Group to examine changes ...
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
(2014-09)
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ...
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
(2013-10)
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ...
Sinusoidal Cox Regression—A Rare Cancer Example
(2010-11)
Evidence of an association between survival time and date of birth would suggest an etiologic role for a seasonally variable environmental exposure occurring within a narrow perinatal time period. Risk factors that may ...
Potential Health Impacts of Heavy Metals on HIV-Infected Population in USA
(2013)
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On-Line Adaptive Radiation Therapy: Feasibility and Clinical Study
(2010)
The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer ...