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The Influence of Diet-Induced Obesity and N-3 Fatty Acids on the Cardiac Mitochondrial Phospholipidome and Respiratory Activity
(East Carolina University, 2017-08-16)
Cardiac mitochondrial phospholipids, notably cardiolipin (CL), regulate inner mitochondrial membrane (IMM) organization and protein function, particularly the enzymes associated with respiration. In a range of metabolic ...
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
(2013)
Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ...
MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
(2014-06)
MuRF1 is a previously reported ubiquitin-ligase found in striated muscle that targets troponin I and myosin heavy chain for degradation. While MuRF1 has been reported to interact with mitochondrial substrates in yeast ...