Browsing Brody School of Medicine by Title
Now showing items 491-510 of 1484
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Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes
(2012)Background The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure ... -
Experimental autoimmune encephalomyelitis as a model of Multiple Sclerosis : pathogenesis of atypical disease and tolerance induction in chronic progressive disease
(East Carolina University, 2015)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin characterized by focal inflammatory lesions together with demyelinating plaques in the ... -
EXPLORING DIFFERENCES IN INDIVIDUAL SUSCEPTIBILITY TO LIPOTOXICITY AND THE UNDERLYING MECHANISMS IN THE MITOCHONDRIA OF PRIMARY PREADIPOCYTES
(East Carolina University, 2018-07-17)Prolonged exposure to fatty acids (FAs), at levels normally seen during fasting, can be cytotoxic in vulnerable cells including preadipocytes. Prior work from our laboratory has shown that FAs cause mitochondrial inner ... -
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
(5/16/2016)Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ... -
Exposure to Concentrated Coarse Air Pollution Particles Causes Mild Cardiopulmonary Effects in Healthy Young Adults
(East Carolina University, 2009-07)Background: There is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter ≤ 2.5 μm (PM2.5)], which derives primarily from combustion processes, can ... -
Expression of hemolysins in vivo and role of HlyBA in an intra-abdominal infection model
(2013-04)Bacteroides fragilis is the most frequent opportunistic pathogen isolated from anaerobic infections. However, there is a paucity of information regarding the genetic and molecular aspects of gene expression of its virulence ... -
Expression of a protein involved in bone resorption, Dkk1, is activated by HTLV-1 bZIP factor through its activation domain
(2010)Background Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, a malignancy characterized by uncontrolled proliferation of virally-infected CD4+ T-cells. Hypercalcemia and bone ... -
Expression of microRNA in Alveolar Macrophages Deficient in PPARy
(East Carolina University, 2014)The nuclear transcription factor Peroxisome proliferator-activated receptor gamma (PPARgamma) is a negative regulator of macrophage activation and inflammatory mediators. Alveolar macrophages of healthy individuals ... -
Extended shelf life platelet preparations and process for preparing the same
(1991-02-19)A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second ... -
The Extracellular Domain of Myelin Oligodendrocyte Glycoprotein Elicits Atypical Experimental Autoimmune Encephalomyelitis in Rat and Species
(2014)Atypical models of experimental autoimmune encephalomyelitis (EAE) are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS). Conversely, models of classical ...