Browsing Brody School of Medicine by Title
Now showing items 63-82 of 1484
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Analysis of the mutation in cutaneous melanoma patients with occupational sun exposure
(2014-03)Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including ... -
Analysis of the Zinc Finger Domain of TnpA, a DNA Targeting Protein Encoded by Mobilizable Transposon Tn4555
(East Carolina University, 2007-07)The mobilizable transposon Tn4555, found in Bacteroides spp., is an important antibiotic resistance element encoding a broad spectrum beta-lactamase. Tn4555 is mobilized by conjugative transposons such as CTn341 which can ... -
ANALYSIS OF TRANSGENIC MOUSE MODELS TO STUDY MAMMALIAN SPERMATOGONIA
(East Carolina University, 2018-07-24)Spermatogenesis in the mammalian testis results in the daily production of millions of spermatozoa. This developmental process is founded upon the actions of a small population of spermatogonial stem cells (SSCs). As SSCs ... -
Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging
(2018-01-05)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
Animal Viruses, Bacteria, and Cancer: A Brief Commentary
(2014-02)Animal viruses and bacteria are ubiquitous in the environment. However, little is known about their mode of transmission and etiologic role in human cancers, especially among high-risk groups (e.g., farmers, veterinarians, ... -
Another dimension to the black Diaspora. Diet, disease, and racism
(East Carolina University, 1983-07) -
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
(East Carolina University, 2008-07)Many chemotherapy drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to ... -
Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells
(East Carolina University, 2009-02)Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases, and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has ... -
Antigen-specific tolerogenic vaccines inhibit autoimmune disease in a rodent model of multiple sclerosis
(East Carolina University, 2010)Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease directed against myelinated nerves within the central nervous system. Current therapies available to MS patients have low efficacy and are ... -
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
(East Carolina University, 2012)The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ... -
Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational Inhibition
(East Carolina University, 2007-01)Cyclooxygenase 2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins, and COX-2 overexpression plays an important role in carcinogenesis. Exposure to UVB strongly increased COX-2 protein expression ... -
Apparatus and method for measuring physiological characteristics of an intact trachea in vitro
(2011-03-15)Apparatus and methods for measuring smooth muscles responses (relaxation and contraction), transepithelial potential difference, and/or transepithelial impedance of an intact trachea in vitro. In particular embodiments, ... -
Applying Community-Based Participatory Research Partnership Principles to Public Health Practice-Based Research Networks
(2016)With real-world relevance and translatability as important goals, applied methodological approaches have arisen along the participatory continuum that value context and empower stakeholders to partner actively with academics ... -
Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries
(East Carolina University, 2009-04)Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This study investigated the impact of arginase on ...