Browsing Brody School of Medicine by Title
Now showing items 813-832 of 1484
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Low adenosine agent, composition, kit and method for treatment of airway disease
(1999-11-30)An oligonucleotide which is antisense to a mRNA encoding a polypeptide involved in airway disease(s) contains up to three adenosines per every 21 nucleotide a method of treating airway disease in a subject in need of such ... -
Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments
(2000-02-24)A composition comprises a nucleic acid comprising an oligo anti-sense to a target such as polypeptide(s) associated with an ailment afflicting lung airways, genes and mRNAs encoding them, genomic and mRNA flanking regions, ... -
Low adenosine anti-sense oligonucleotide, compositions, kit and method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) and surfactant depletion
(2000-10-26)An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA comprises the topical admistration, e.g. to the respiratory system, of a subject of a therapeutic amount of an oligonucleotide that is ... -
Lyme Disease Pathogenesis
(2021) -
Lymphocytic hypophysitis.
(East Carolina University, 1994-05)LYMPHOCYTIC HYPOPHYSITIS is an unusual disorder that nearly exclusively affects women; fewer than 50 cases have been reported in the literature. The present case also is unusual because a normal computed tomographic (CT) ... -
Macrophage Regulation in the Murine Inflammatory Response
(East Carolina University, 2018-08-30)The development of acute and chronic liver disease is a complex condition involving the dysregulation of hepatic metabolism and the accumulation of critical immune cells; specifically, the recruitment and activation of ... -
Make sure multi-vitamin delivers what you need.
(2023-07-19)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column answers two questions. First are multi vitamins delivered through a gummy as good as those in a pill. The second was about ... -
Malnutrition defined by dietary problems, not just starvation
(2023-06-14)This newspaper column written by Ashley Strickland RDN, CDN, CNSC explains how and why a person being admitted to the hospital may be screened for malnutrition or hidden nutrition and how it is managed at ECU Health. This ... -
Mast cells and the IL-33/ST2 axis are essential determinants of carbon nanotube toxicity
(East Carolina University, 2012)The rise of nanomaterial use in a variety of applications, including biomedical imaging and drug delivery, has led to concern about the potentially hazardous impacts on human health. Mast cells are critical for innate and ... -
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight
(2015-07)Background Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter ... -
A Mathematical Model of Tumor Volume Changes during Radiotherapy
(2013)Purpose. To develop a clinically viable mathematical model that quantitatively predicts tumor volume change during radiotherapy in order to provide treatment response assessment for prognosis, treatment plan optimization, ... -
Matrix Metalloproteinase 12 is Critical for Granuloma Formation in the Murine Model of Granulomatous disease
(East Carolina University, 2019-08-16)Matrix Metalloproteinase 12 (MMP12) is a protein produced primarily by alveolar macrophages that degrades elastin in the extracellular matrix (ECM) and enables infiltration of immune cells that participate in the inflammatory ... -
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.
(East Carolina University, 1995-04)Increased protein kinase C (PKC) activity in malignant breast tissue and positive correlations between PKC activity and expression of a more aggressive phenotype in breast cancer cell lines suggest a role for this signal ...