Browsing Brody School of Medicine by Title
Now showing items 933-952 of 1484
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Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment
(2015-05)Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role ... -
Muscle Mitochondria in Vascular Disease: A Novel Genetic Target for Limb Salvage
(East Carolina University, 2022-04-19)Peripheral arterial occlusive disease (PAD) is a manifestation of systemic atherosclerosis defined by an occlusion in the peripheral arteries, most commonly those supplying blood to the lower extremities. Chronic limb ... -
Mushrooms may be good medicine
(2020-09-09)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is about medicinal mushrooms and some if the potential benefits and risks, especially related to cancer and neurogenerative ... -
Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
(2012-09)The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, ... -
N-3 polyunsaturated fatty acids differentially enhance B-cell mediated immunity in lean and obese mice
(East Carolina University, 2014)Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are bioactive n-3 polyunsaturated fatty acids (PUFAs) in fish oil that exert immunomodulatory effects. The general paradigm suggests n-3 PUFAs exert immunosuppressive ... -
Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma
(2012-08)NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant ... -
The Need for Interprofessional Collaborative Ready Nutrition and Dietetics Practitioners
(2014-10-01)This is the full length paper of what turned out to be a published brief after going through peer review. Many of our colleagues have requested the original full length description which is more of a call to action for ... -
Negative Charges at Protein Kinase C Sites of Troponin I Stabilize the Inactive State of Actin
(East Carolina University, 2008-01-15)Alterations in the troponin complex can lead to increases or decreases in contractile activity. Most mutations of troponin that cause hypertrophic cardiomyopathy increase the activity of cardiac muscle fibers. In at least ... -
A Neo-Searlean Theory of Intentionality
(2022-03-14)I present Searle’s theory of intentionality and defend it against some objections. I then significantly extend his theory by exposing and incorporating an ambiguity in the question as to what an intentional state is about ... -
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
(2011)Background Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease ... -
Neurogenic inflammation and sensitivity to environmental chemicals.
(East Carolina University, 1993-08)Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. ... -
Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity.
(East Carolina University, 1995-01)Neurogenic switching is proposed as a hypothesis for a mechanism by which a stimulus at one site can lead to inflammation at a distant site. Neurogenic inflammation occurs when substance P and other neuropeptides released ... -
Neuropeptide Y analogues, compositions and methods of lowering blood pressure
(2000-06-13)Neuropeptide Y analogues, and their compositions are effective for lower blood pressure.