Browsing Brody School of Medicine by Title
Now showing items 607-626 of 884
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p53 and NGAL: dual regulatory roles in advanced prostate cancer
(East Carolina University, 2011)The development of prostate cancer from small regions of hyperplasia to invasive tumors requires genetic and epigenetic alterations of critical cellular components to aid in the development of cells more adapted for aberrant ... -
A Pacific Food Guide from the Children's Healthy Living PRogram
(2016-02)The paper describes the development of the Pacific Food Guide. The Food Guide includes fruits, vegetables, fish and animals not typically found in the US Food Guides but are consumed by individuals living int the Pacific. ... -
Participation in Community-Originated Interventions is Associated with Positive Changes in Weight Status and Health Behaviors in Youth
(2012-04-13)Purpose. To assess changes in children’s health behaviors and weight status after participation in community-originated interventions. ... -
Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
(East Carolina University, 2014)It is currently estimated that a third of Americans suffer from metabolic syndrome, which is an obesogenic disease shown to increase risk for developing type 2 diabetes (T2DM) by five-fold (Diabetes Care, 2012). The ... -
Patient and Practice Perspectives on Strategies for Controlling Blood Pressure, North Carolina, 2010–2012
(2014)Introduction Patient and practice perspectives can inform development of team-based approaches to improving blood pressure control in primary care. We used a community-based participatory research approach to assess patient ... -
Patterns of Distress in African American Mothers of Preterm Infants
(East Carolina University, 2009-06)Objective: To examine inter-relationships among stress due to infant appearance and behavior in the NICU, parental role alteration stress in the NICU, depressive symptoms, state anxiety, posttraumatic stress symptoms, and ... -
Patterns of Pelvic Radiotherapy in Patients with Stage II/III Rectal Cancer
(2013)High-level evidence supports adjuvant radiotherapy for rectal cancer. We examined the influence of sociodemographic factors on patterns of adjuvant radiotherapy for resected Stage II/III rectal cancer. Methods. Patients ... -
Peat Bog Wildfire Smoke Exposure in Rural North Carolina Is Associated with Cardiopulmonary Emergency Department Visits Assessed through Syndromic Surveillance
(2011-10)Background: In June 2008, burning peat deposits produced haze and air pollution far in excess of National Ambient Air Quality Standards, encroaching on rural communities of eastern North Carolina. Although the association ... -
Perceptions of the Community Food Environment and Related Influences on Food Choice Among Midlife Women Residing in Rural and Urban Areas: A Qualitative Analysis
(East Carolina University, 2009)Introduction—Qualitative research on food choice has rarely focused on individuals’ perceptions of the community food environment. Women remain gatekeepers of the family diet and food purchasing. Therefore we assessed ... -
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
(East Carolina University, 2013)Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ... -
Perforated gastric corpus in a strangulated paraesophageal hernia: a case report
(East Carolina University, 2009-05-07)Introduction: Patients with paraesophageal hernias often present secondary to chronic symptomatology. Infrequently, acute intestinal ischemia and perforation can occur as a consequence of paraesophageal hernias with ... -
Peripheral Arterial Disease and Risk of Atrial Fibrillation and Stroke: The Multi�Ethnic Study of Atherosclerosis
(2014-12)Background Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for ... -
Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
(East Carolina University, 2019-07-03)Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ... -
Peroxisome Proliferator-Activated Receptor-γ Regulates the Expression of Alveolar Macrophage Macrophage Colony- Stimulating Factor
(East Carolina University, 2008-07-01)Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) and in the GMCSF knockout mouse, a murine ... -
Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression
(2013)There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone ... -
Pharmaceutically acceptable fixed-dried human blood platelets
(1999-11-30)Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution; adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change ... -
Pharmacological Regulation of Neural Circuit Formation in hIPSC-Derived Neurons and ‘Mini-Brains’
(East Carolina University, 2018-07-20)Emerging evidence suggests that altered neural connectivity, particularly at the level of synaptic connections, contributes to the pathology of many neurodevelopmental and neurodegenerative diseases. For instance, post-mortem ... -
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
(East Carolina University, 1995-10)Protein kinase C (PKC) modulates growth, differentiation, and apoptosis in a cell-specific fashion. Overexpression of PKC-a in MCF-7 breast cancer cells (MCF-7-PKC-a cell) leads to expression of a more transformed phenotype. ...