Browsing Brody School of Medicine by Author "Anderson, Ethan"
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Animal Viruses, Bacteria, and Cancer: A Brief Commentary
Efird, Jimmy T.; Davies, Stephen W.; O'Neal, Wesley T.; Anderson, Ethan (2014-02)Animal viruses and bacteria are ubiquitous in the environment. However, little is known about their mode of transmission and etiologic role in human cancers, especially among high-risk groups (e.g., farmers, veterinarians, ... -
The “Goldilocks Zone� from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle
Alleman, Rick J.; Katunga, Lalage Adalaide; Nelson, Margaret A. M.; Brown, David A.; Anderson, Ethan (2014-09)Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ... -
Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
Mattox, Taylor A. (East Carolina University, 2014)Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ... -
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
Katunga, Lalage Adalaide (5/16/2016)Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ... -
A Genotype–Phenotype Analysis of Glutathione Peroxidase 4 in Human Atrial Myocardium and Its Association with Postoperative Atrial Fibrillation
Akhter, Shahab A.; Berdaweel, Islam A.; Hart, Alexander A.; Jatis, Andrew J.; Karlan, Nathan; Gaine, Marie E.; Smith, Ryan M.; Anderson, Ethan (2022-04-06) -
Increased Coronary Artery Disease Severity in Black Women Undergoing Coronary Bypass Surgery
Efird, Jimmy T.; O'Neal, Wesley T.; Griffin, William F.; Anderson, Ethan; Davies, Stephen W.; Landrine, Hope; O'Neal, Jason B.; Shiue, Kristin Y.; Kindell, Linda C.; Bruce Ferguson, T.; Randolph Chitwood, W.; Kypson, Alan P. (2015-02)Race and sex disparities are believed to play an important role in heart disease. The purpose of this study was to examine the association between race, sex, and number of diseased vessels at the time of coronary artery ... -
Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents
Efird, Jimmy T.; Griffin, William F.; Sarpong, Daniel F.; Davies, Stephen W.; Vann, Iulia; Koutlas, Nathaniel T.; Anderson, Ethan; Crane, Patricia B.; Landrine, Hope; Kindell, Linda C.; Iqbal, Zahra J.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2015-07)The aim of this study was to examine racial differences in long-term mortality after coronary artery bypass grafting (CABG), stratified by preoperative use of inotropic agents. Black and white patients who required ... -
Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner
Bikman, Benjamin Thomas; Zheng, Donghai; Kane, Daniel A.; Anderson, Ethan; Woodlief, Tracey L.; Price, Jesse W.; Dohm, G. Lynis; Neufer, P. Darrell; Cortright, Ronald N. (2010)Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ... -
Methods for preventing or treating insulin resistance
Neufer, P. Darrell; Anderson, Ethan; Szeto, Hazel (2009-08-13)The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one ... -
Methods of using carnosinol and analogs thereof
Anderson, Ethan; Katunga, Lalage; Aldini, Giancarlo (2015-12-17)Embodiments of the present invention relate to methods of preventing or treating diabetes, an obesity/diabetes-related condition, insulin sensitivity, heart disease, mitochondrial dysfunction or liver disease comprising ... -
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Anderson, Ethan; Lustig, Mary E.; Boyle, Kristen E.; Woodlief, Tracey L.; Kane, Daniel A.; Lin, Chien-Te; Price, Jesse W. III; Kang, Li; Rabinovitch, Peter S.; Szeto, Hazel H.; Houmard, Joseph A.; Cortright, Ronald N.; Wasserman, David H.; Neufer, P. Darrell (2009-03)High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ... -
Monoamine Oxidase is a Major Determinant of Redox Balance in Human Atrial Myocardium and is Associated With Postoperative Atrial Fibrillation
Anderson, Ethan; Efird, Jimmy T.; Davies, Stephen W.; O'Neal, Wesley T.; Darden, Timothy M.; Thayne, Kathleen A.; Katunga, Lalage Adalaide; Kindell, Linda C.; Ferguson, T. Bruce; Anderson, Curtis A.; Chitwood, W. Randolph; Koutlas, Theodore C.; Williams, J. Mark; Rodriguez, Evelio; Kypson, Alan P. (2014-02)BACKGROUND: Onset of postoperative atrial fibrillation (POAF) is a common and costly complication of heart surgery despite major improvements in surgical technique and quality of patient care. The etiology of POAF, and ... -
MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
Mattox, Taylor A.; Young, Martin E.; Rubel, Carrie E.; Spaniel, Carolyn; Rodriguez, Jessica E.; Grevengoed, Trisha J.; Gautel, Mathias; Xu, Zhelong; Anderson, Ethan; Willis, Monte S. (2014-06)MuRF1 is a previously reported ubiquitin-ligase found in striated muscle that targets troponin I and myosin heavy chain for degradation. While MuRF1 has been reported to interact with mitochondrial substrates in yeast ... -
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
Fisher-Wellman, Kelsey H.; Mattox, Taylor A.; Thayne, Kathleen; Katunga, Lalage Adalaide; La Favor, Justin D.; Neufer, P. Darrell; Hickner, Robert C.; Wingard, Christopher J.; Anderson, Ethan (2013)Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ... -
Obesity in a model of haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Katunga, Lalage Adalaide; Gudimella, Preeti; Efird, Jimmy T.; Abernathy, Scott; Mattox, Taylor A.; Beatty, Cherese; Darden, Timothy M.; Thayne, Kathleen A.; Alwair, Hazaim; Kypson, Alan P.; Virag, Jitka A. I.; Anderson, Ethan (2015-04)Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme ... -
Potential for Improved Glycemic Control with Dietary in Patients with Insulin Resistance and Pre-Diabetes
Efird, Jimmy T.; Choi, Yuk Ming; Davies, Stephen W.; Mehra, Sanjay; Anderson, Ethan; Katunga, Lalage Adalaide (2014-02)Bitter Melon (Momordica charantia) is a widely used traditional remedy for hyperglycemia. While the medicinal properties of this plant have been studied extensively using in vitro and animal models, the clinical efficacy ... -
Prohibitin-1 Is a Dynamically Regulated Blood Protein with Cardioprotective Effects in Sepsis
Mattox, Taylor A.; Psaltis, Christine; Robidoux, Jacques; Kilburg-Basnyat, Brita; Gowdy, Kymberly M.; Weihbrecht, Katie; Murphy, Michael P.; Anderson, Ethan (2021) -
Use of monoamine oxidase and redox enzymes in atrial tissue as novel predictors of postoperative atrial fibrillation
Darden, Timothy M. (East Carolina University, 2014)Postoperative atrial fibrillation (POAF) occurs in approximately 30% of cardiac surgery patients. The complication occurs despite advances in surgical procedures. It is associated with increased mortality, morbidity, and ...