Browsing Brody School of Medicine by Author "Baldwin, Cynthia L."
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Genetic Organization and Iron-Responsive Regulation of the Brucella abortus 2,3-Dihydroxybenzoic Acid Biosynthesis Operon, a Cluster of Genes Required for Wild-Type Virulence in Pregnant Cattle
Bellaire, Bryan H.; Elzer, Philip H.; Hagius, Sue; Walker, Joel; Baldwin, Cynthia L.; Roop, R. Martin II (East Carolina University, 2003-04)Brucella abortus reportedly produces the monocatechol siderophore 2,3-dihydroxybenzoic acid (2,3-DHBA) in response to iron limitation. Nucleotide sequence analysis of the cloned DHBA biosynthesis locus from virulent B. ... -
Production of the Siderophore 2,3-Dihydroxybenzoic Acid Is Required for Wild-Type Growth of Brucella abortus in the Presence of Erythritol under Low-Iron Conditions In Vitro
Bellaire, Bryan H.; Elzer, Philip H.; Baldwin, Cynthia L.; Roop, R. Martin II (East Carolina University, 2003-05)Production of the siderophore 2,3-dihyroxybenzoic acid (2,3-DHBA) is required for the wild-type virulence of Brucella abortus in cattle. A possible explanation for this requirement was uncovered when it was determined that ...