Browsing Brody School of Medicine by Author "Thomassen, Mary Jane"
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Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes
Dalrymple, Heidi; Barna, Barbara P.; Malur, Anagha; Malur, Achut G.; Kavuru, Mani S.; Thomassen, Mary Jane (2013)Background Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar ... -
Can GPR4 Be a Potential Therapeutic Target for COVID-19?
Yang, Li V.; Oppelt, Karen A.; Thomassen, Mary Jane; Marie, Mona A.; Nik Akhtar, Shayan; McCallen, Justin D. (2021-01-21) -
Carbon Nanotube-Induced Pulmonary Granulomatous Disease: 1 and Alveolar Macrophage M1 Activation
Barna, Barbara P.; Huizar, Isham; Malur, Anagha; McPeek, Matthew; Marshall, Irene; Jacob, Mark; Dobbs, Larry; Kavuru, Mani S.; Thomassen, Mary Jane (2013-12)Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially ... -
Elevated MicroRNA-33 in Sarcoidosis and a Carbon Nanotube Model of Chronic Granulomatous Disease
Bowling, Mark R.; Barna, Barbara P.; McPeek, Matthew; Malur, Anagha; Wingard, Christopher J.; Dobbs, Larry; Verbanac, Kathryn M.; Thomassen, Mary Jane (2016-06-01) -
Expression of microRNA in Alveolar Macrophages Deficient in PPARy
McPeek, Matthew (East Carolina University, 2014)The nuclear transcription factor Peroxisome proliferator-activated receptor gamma (PPARgamma) is a negative regulator of macrophage activation and inflammatory mediators. Alveolar macrophages of healthy individuals ... -
Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
Li, Jian; Sai, Tao; Berger, Marc; Chao, Qimin; Davidson, Diane; Deshmukh, Gaurav; Drozdowski, Brian; Ebel, Wolfgang; Harley, Stephen; Henry, Marianne; Jacob, Sara; Kline, Brad; Lazo, Ella; Rotella, Frank; Routhier, Eric; Rudolph, Kathryn; Sage, Jeaneen; Simon, Paul; Yao, Jun; Zhou, Yuhong; Kavuru, Mani S.; Bonfield, Tracey L.; Thomassen, Mary Jane; Sass, Philip M.; Nicolaides, Nicholas C.; Grasso, Luigi (East Carolina University, 2006-03-07)Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage ... -
The M2a Macrophage Phenotype Accompanies Pulmonary Granuloma Resolution in Mmp12 Knock-Out Mice Instilled with Multiwall Carbon Nanotubes
Ogburn, David; Bhalla, Sophia; Leffler, Nan; Mohan, Arjun; Malur, Anagha; Malur, Achut G.; McPeek, Matthew; Barna, Barbara P.; Thomassen, Mary Jane (2021-10-13) -
Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model
Soliman, Eman; Bhalla, Sophia; Malur, Anagha; Ogburn, David; Leffler, Nancy; Thomassen, Mary Jane; Elhassanny, Ahmed E. M.; Malu, Achut G. (2022) -
Peroxisome Proliferator-Activated Receptor-γ Regulates the Expression of Alveolar Macrophage Macrophage Colony- Stimulating Factor
Bonfield, Tracey L.; Thomassen, Mary Jane; Farver, Carol F.; Abraham, Susamma; Koloze, Mary T.; Zhang, Xia; Mosser, David M.; Culver, Daniel A. (East Carolina University, 2008-07-01)Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) and in the GMCSF knockout mouse, a murine ... -
Review: Carbon Nanotubes and Chronic Granulomatous Disease
Barna, Barbara P.; Judson, Marc A.; Thomassen, Mary Jane (2014-06-23)Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles ... -
Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
Malur, Anagha; Kavuru, Mani S.; Marshall, Irene; Barna, Barbara P.; Huizar, Isham; Karnekar, Reema; Thomassen, Mary Jane (2012)Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
Huizar, Isham; Malur, Anagha; Patel, Janki; McPeek, Matthew; Dobbs, Larry; Wingard, Christopher J.; Barna, Barbara P.; Thomassen, Mary Jane (2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ...