Search
Now showing items 81-90 of 223
Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats
(East Carolina University, 2001-12)
1 Isolated aortic rings (endothelium-intact and -denuded) from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used in this study to examine the vasoactive e ects of various adenosine analogues. 2 In ...
The RXR-alpha C-terminus T462 is a NMR sensor for coactivator peptide binding
(East Carolina University, 2008-02-22)
The C-terminal activation function-2 (AF-2) helix plays a crucial role in retinoid X receptor alpha (RXRα)-mediated gene expression. Here, we report a nuclear magnetic resonance (NMR) study of the RXRα ligand-binding domain ...
A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm
(East Carolina University, 2009-05-15)
Fertility and embryonic viability are measures of efficient germ cell growth and development. During oogenesis and spermatogenesis, new proteins are required for both mitotic expansion and differentiation. Qualitative and ...
Functional Characterization of a Small Conductance GIRK Channel in Rat Atrial Cells
(East Carolina University, 2004-11)
Muscarinic K1 (KACh) channels are key determinants of the inhibitory synaptic transmission in the heart. These channels are heterotetramers consisting of two homologous subunits, G-protein-gated inwardly rectifying K1 ...
Negative Charges at Protein Kinase C Sites of Troponin I Stabilize the Inactive State of Actin
(East Carolina University, 2008-01-15)
Alterations in the troponin complex can lead to increases or decreases in contractile activity. Most mutations of
troponin that cause hypertrophic cardiomyopathy increase the activity of cardiac muscle fibers. In at least ...
HuR binds to a single site on the C/EBP - beta mRNA of 3T3-L1 Adipocytes
(East Carolina University, 2007-03-30)
HuR is a ligand for nuclear mRNAs containing adenylate-uridylate rich elements in the 3'- untranslated region. Once bound to the mRNA, HuR is recognized by adapter proteins which then facilitate nuclear export of the ...
Invasion and Intracellular Survival of Burkholderia cepacia
(East Carolina University, 2000-01)
Burkholderia cepacia has emerged as an important pulmonary pathogen in immunocompromised patients
and in patients with cystic fibrosis (CF). Little is known about the virulence factors and pathogenesis of B.
cepacia, ...
Production of the Siderophore 2,3-Dihydroxybenzoic Acid Is Required for Wild-Type Growth of Brucella abortus in the Presence of Erythritol under Low-Iron Conditions In Vitro
(East Carolina University, 2003-05)
Production of the siderophore 2,3-dihyroxybenzoic acid (2,3-DHBA) is required for the wild-type virulence of Brucella abortus in cattle. A possible explanation for this requirement was uncovered when it was determined that ...
Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance
(East Carolina University, 2007-08)
Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ...
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
(East Carolina University, 2009-01)
Since the discovery of leukemic stem cells (LSCs) over a decade ago, many of their critical biological
properties have been elucidated, including their distinct replicative properties, cell surface
phenotypes, their ...