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Delta-Catenin Induced Dendritic Morphogenesis: An Essential Role of p190RhoGEF Interaction through Akt1 Mediated Phosphorylation
(East Carolina University, 2008-01-11)
delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin ...
Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids
(East Carolina University, 2008-01-31)
Background: Spermatogenesis is comprised of a series of highly regulated developmental changes that transform the precursor germ cell into a highly specialized spermatozoon. The last phase of spermatogenesis, termed ...
The Influence of Iron on Pseudomonas aeruginosa Physiology: A regulatory link between iron and quorum sensing
(East Carolina University, 2008-06-06)
In iron-replete environments, the Pseudomonas aeruginosa Fur (ferric uptake regulator) protein represses expression of two small regulatory RNAs encoded by prrF1 and prrF2. Here we describe the effects of iron and PrrF ...
Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
(East Carolina University, 2008-12)
Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ...
Hox-gene expression as a biomarker for igf-1r therapeutics
(2008-09-25)
This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or ...
Method of detecting cancer using delta-catenin
(2008-11-04)
The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from ...
Synergistic Proapoptotic Activity of Recombinant Trail Plus the AKT Inhibitor Perifosine in Acute Myelogenous Leukemia Cells
(East Carolina University, 2008-11-15)
To potentiate the response of acute myelogenous leukemia (AML) cells to TNF-Related Apoptosis- Inducing Ligand (TRAIL) cytotoxicity, we have examined the efficacy of a combination with perifosine, a novel phosphatidylinositol ...
Radiation isocenter measurement devices and methods and 3-D radiation isocenter visualization systems and related methods
(2008-05-25)
A three-dimensional phantom assembly for use with a radiation treatment device includes a three-dimensional support member having at least two, spaced apart opposed surfaces configured to hold at least one generally planar ...
Type.Cast: The Heart of Medicine (2008)
(2008)
An art and literary magazine published by the Brody School of Medicine, Division of Health Sciences. The magazine contains artwork and writings by Brody School of Medicine's medical students.
Fixed-dried red blood cells
(2008-04-15)
Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial ...