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Diabetes Education in Rural Appalachia
(2010-10-28)
Introduction:
Diabetes education has long been a problem at rural health sites like Tug River Health Association at Gary, WV. Many providers expressed a need of handouts on diabetic topics that are both informative and ...
Fesselin and caldesmon: natively unfolded proteins in smooth muscle regulation
(East Carolina University, 2010)
Dysregulation of smooth muscle contraction is linked to diseases such as atherosclerosis, asthma, hypertension, urinary incontinence, premature birth and others. The goal of this project is to contribute to our understanding ...
Mechanisms for central cannabinoid receptor 1 evoked sympathoexcitation/pressor response in conscious rats
(East Carolina University, 2010)
The main goal of the current study was to elucidate the molecular mechanisms implicated in central cannabinoid receptor 1 (CB1R)-evoked sympathoexcitation/pressor response. In pursuit of this goal, the candidate first ...
Endometrial carcinoma in vitro chemosensitivity testing of single and combination chemotherapy regimens using the novel microculture kinetic apoptosis assay: implications for endometrial cancer treatment
(East Carolina University, 2010-03)
Objective: The in vitro microculture kinetic (MiCK) apoptosis assay has been used to predict single or combination chemotherapy response in leukemia patients. This feasibility study addressed MiCK in endometrial cancer ...
Oxytocin Modulation of Zebra Finch Vocal Development
(East Carolina University, 2010)
Autism spectrum disorder is associated with deficits in three main behavioral areas: social behaviors, repetitive behaviors, and language abnormalities. Accumulating evidence suggests a potential role for oxytocin signaling ...
Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)
The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ...
Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases
(East Carolina University, 2010-05)
Backgroundâ Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced
formation of reactive oxygen species (ROS) that attack DNA leading to cell death. As the diversity
of IR applied in medicine, ...
Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner
(East Carolina University, 2010-04-12)
Background: Elevated levels of air pollution are associated with increased risk of lung cancer. Particulate matter (PM)
contains transition metals that may potentiate neoplastic development through the induction of oxidative ...
Comparison of tolerance characteristics in the guinea pig following chronic in-vivo exposure to opioid versus cannabinoid receptor agonists
(East Carolina University, 2010)
Few studies have compared the nature of tolerance that develops following chronic in vivo opioid treatment with that which develops after chronic cannabinoid exposure in the same tissue and species. Based on similarities ...
Blood Pressure Control in Diabetes
(2010-04)
OBJECTIVE Despite widespread dissemination of target values, achieving a blood pressure of <130/80 mmHg is challenging for many individuals with diabetes. The purpose of the present study was to examine temporal trends in ...