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Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)
Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ...
INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
(East Carolina University, 2022-06-27)
Spermatogonia differentiation and meiotic initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional ...
HUMAN RNA METHYLTRANSFERASE METTL16 AFFECTS MULTIPLE CELL PROCESSES THROUGH DIFFERENTIAL FUNCTION OF ITS DOMAINS
(East Carolina University, 2022-11-10)
ABSTRACT
In recent years, disease therapies have been developed to target specific RNA and protein expression changes in the affected cells/tissue. The RNA post-transcriptional modification, methyl-6-adenosine (m6A), has ...
Accuracy of Wet Bulb Globe Temperature (WBGT) Obtained from Regional Weather Station Data for Agricultural Settings in Eastern North Carolina as Proxy for WBGT Obtained from Local Heat Stress Monitors
(East Carolina University, 2022-12-01)
Introduction:
Agricultural workers are at high risk of suffering from heat stress and subsequently developing heat-related illnesses (HRIs) due to the outdoor nature of their work. This risk can be exacerbated in hot, ...
A Wzx-Wzy-like Polysaccharide Biosynthetic Pathway Contributes to Virulence in Brucella abortus 2308 through an Unknown Mechanism
(East Carolina University, 2022-08-05)
Brucella abortus is an intracellular pathogen that causes spontaneous abortion in cattle and undulant fever in humans. As a member of the a-proteobacteria, B. abortus is closely related to the bacterial species Caulobacter ...
Retrospective Risk Assessment of Forestry Workers in the United States: Injuries, Fatalities, and Hazards Impacting Occupational Health
(East Carolina University, 2022-12-02)
Forestry (including logging) is one of the most hazardous occupations due to environmental, ergonomic, chemical, mechanical, mental, and physical components of the job. In the United States (US), workplace injuries account ...
Evaluation of the use of Wastewater Based Epidemiology as a Surveillance Tool and the Potential effects of Vaccines and Students Beliefs and Practices in Mitigating the Spread of COVID-19 Among Students at East Carolina University
(East Carolina University, 2022-12-01)
Worldwide, newly emerging and re-emerging infectious diseases and pathogens have led to increases in the number and frequency of disease outbreaks. Although these disease outbreaks are not new, increases in outbreaks have ...
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)
Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ...