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Now showing items 1481-1483 of 1483
STRUCTURE-FUNCTION ANALYSIS OF A FAMILY OF BORRELIAL C1r INHIBITORS FROM LYME DISEASE AND RELAPSING FEVER SPIROCHETES
(East Carolina University, 2023-06-01)
The complement system is an ancient part of the innate immune system consisting of fluid-phase proteins that contribute to inflammation, homeostasis, and pathogen clearance. A group of vector-borne spirochetal pathogens ...
TLR-4 agonism induces CD25+ MHCIIhigh dendritic cells in association with tolerogenic antigen recognition
(East Carolina University, 2022-12-06)
Autoimmune disease is a result of the breakdown in immunological self-tolerance leading to destruction of self-tissues mediated by the aberrant immune attack. In Multiple Sclerosis (MS), CD4+ T cells mediate destruction ...