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Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression
(2013)
There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone ...
Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis
(East Carolina University, 2016-08-18)
Lyme disease is the most prevalent vector-borne disease in United States and is caused by the spirochete Borrelia burgdorferi. The disease is transmitted from an infected Ixodes scapularis tick to a mammalian host. B. ...
Linking energy state to redox environment through mitochondrial redox circuits
(East Carolina University, 2016-11-16)
Mitochondria are the primary producers of intracellular H2O2, an oxidant signaling molecule that has gained attention for its role in normal physiological processes and disease etiologies such as skeletal muscle insulin ...
Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration
(East Carolina University, 2016-09-08)
Cardiovascular disease (CVD) is a multi-faceted pathology that remains the number one killer of all Americans and people worldwide. Vascular inflammation, endothelial dysfunction, extracellular matrix imbalance, and arterial ...
Applying Community-Based Participatory Research Partnership Principles to Public Health Practice-Based Research Networks
(2016)
With real-world relevance and translatability as important goals, applied methodological approaches have arisen along the
participatory continuum that value context and empower stakeholders to partner actively with academics ...
Advancing Research on Racial–Ethnic Health Disparities: Improving Measurement Equivalence in Studies with Diverse Samples
(2014-12)
To conduct meaningful, epidemiologic research on racial–ethnic health disparities, racial–ethnic samples must be rendered equivalent on other social status and contextual variables via statistical controls of those extraneous ...
CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
(East Carolina University, 2016-12-15)
Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ...
A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project
(2016-08-05)
Abstract
Background
Because residents of the southeastern United States experience disproportionally high rates of cardiovascular disease (CVD), it is important to develop ...
Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury
(2016-08-24)
Background:The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability ...
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight
(2015-07)
Background
Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter ...