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Analysis of the Zinc Finger Domain of TnpA, a DNA Targeting Protein Encoded by Mobilizable Transposon Tn4555
(East Carolina University, 2007-07)
The mobilizable transposon Tn4555, found in Bacteroides spp., is an important antibiotic resistance element encoding a broad spectrum beta-lactamase. Tn4555 is mobilized by conjugative transposons such as CTn341 which can ...
What Constitutes an Extended-Spectrum beta-lactamase?
(East Carolina University, 2002-02)
Aerobic-Type Ribonucleotide Reductase in the Anaerobe Bacteroides fragilis
(East Carolina University, 2002-02)
Bacteroides fragilis, a component of the normal intestinal flora, is an obligate anaerobe capable of long-term survival in the presence of air. Survival is attributed to an elaborate oxidative stress response that controls ...
Thioredoxin Reductase Is Essential for Thiol/Disulfide Redox Control and Oxidative Stress Survival of the Anaerobe Bacteroides fragilis
(East Carolina University, 2007-11)
Results of this study showed that the anaerobic, opportunistic pathogen Bacteroides fragilis lacks the
glutathione/glutaredoxin redox system and possesses an extensive number of putative thioredoxin (Trx)
orthologs. ...
The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis
(East Carolina University, 2000-09)
The peroxide response-inducible genes ahpCF, dps, and katB in the obligate anaerobe Bacteroides fragilis are
controlled by the redox-sensitive transcriptional activator OxyR. This is the first functional oxidative ...
Characterization of Bacteroides fragilis Hemolysins and Regulation and Synergistic Interactions of HlyA and HlyB
(East Carolina University, 2006-04)
This study describes the presence of 10 hemolysin orthologs in the genome of the opportunistic human anaerobic pathogen Bacteroides fragilis, which is currently classified as a nonhemolytic bacterium. The hemolysins were ...
A Multicomponent System Is Required for Tetracycline-Induced Excision of Tn4555
(East Carolina University, 2004-01)
Bacteroides spp. are the predominant organisms in the intestinal tract, and they also are important opportunistic
pathogens. Antibiotic therapy of Bacteroides infections often is complicated by the prevalence of
drug-resistant ...
Characterization of the Primary Starch Utilization Operon in the Obligate Anaerobe Bacteroides fragilis: Regulation by Carbon Source and Oxygen
(East Carolina University, 2006-07)
The opportunistic pathogen Bacteroides fragilis is a commensal organism in the large intestine, where it utilizes both dietary and host-derived polysaccharides as a source of carbon and energy. In this study, a four-gene ...