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N-3 polyunsaturated fatty acids differentially enhance B-cell mediated immunity in lean and obese mice
(East Carolina University, 2014)
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are
bioactive n-3 polyunsaturated fatty acids (PUFAs) in fish oil that
exert immunomodulatory effects. The general paradigm suggests n-3
PUFAs exert immunosuppressive ...
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
(East Carolina University, 2014)
Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ...
Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
(East Carolina University, 2014)
Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ...
Interrelated role of Notch signaling and mTORC pathways in prostate cancer cell survival and growth
(East Carolina University, 2014)
Prostate cancer is currently the second highest leading cause of
cancer death in men. Notch is a transmembrane receptor protein that
is part of a signaling pathway necessary in the normal development of
the prostate. ...
Proctitis following stereotactic body radiation therapy for prostate cancer
(2014-12)
Background
Proctitis after radiation therapy for prostate cancer remains an ongoing clinical challenge and critical quality of life issue. SBRT could minimize rectal toxicity by reducing the volume of rectum receiving ...
Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
(2014-01)
Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated ...
PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells
(2014-06)
PLC-beta 1 (PLCβ1) inhibits in human K562 cells erythroid differentiation induced by mithramycin (MTH) by targeting miR-210 expression. Inhibition of miR-210 affects the erythroid differentiation pathway and it occurs to ...
Emerging targeted therapies for melanoma treatment (Review)
(2014-08)
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development ...
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
(2014-09)
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ...
Differentiation-dependent Requirement of Tsix long non-coding RNA in Imprinted X-chromosome Inactivation
(2014-06)
Imprinted X-inactivation is a paradigm of mammalian transgenerational epigenetic regulation resulting in silencing of genes on the paternally-inherited X-chromosome. The pre-programmed fate of the X-chromosomes is thought ...