Browsing Anatomy and Cell Biology by Title
Now showing items 42-61 of 66
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A non-tight junction function of claudin-7—Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
(2015-06-17)Background Claudins are a family of tight junction (TJ) membrane proteins involved in a broad spectrum of human diseases including cancer. Claudin-7 is a unique TJ membrane protein in that it has a strong basolateral ... -
A Novel A1 Adenosine Receptor Antagonist, L-97-1 [3-[2-(4-Aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], Reduces Allergic Responses to House Dust Mite in an Allergic Rabbit Model of Asthma
(East Carolina University, 2005-10)Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics. Adenosine produces bronchoconstriction in allergic rabbits, primates, and humans by activating A1 adenosine receptors (ARs). ... -
Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats
(East Carolina University, 2006-01)Background: Previous studies have shown that testosterone enhances baroreflex bradycardia. Therefore, conscious unrestrained rats were used to investigate the role of the androgen receptor in the testosterone-mediated ... -
Pharmacological Regulation of Neural Circuit Formation in hIPSC-Derived Neurons and ‘Mini-Brains’
(East Carolina University, 2018-07-20)Emerging evidence suggests that altered neural connectivity, particularly at the level of synaptic connections, contributes to the pathology of many neurodevelopmental and neurodegenerative diseases. For instance, post-mortem ... -
PPP1R2 COORDINATES KINASE AND PHOSPHATASE ACTIVITY TO REGULATE THE CENTROSOME AND MIDBODY
(East Carolina University, 2021-04-21)Centrosomes are the primary microtubule organizing centers of the cell and prepare the cell for division by establishing the bipolar spindle during mitosis. A balance of kinase and phosphatase activity regulates centrosome ... -
PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics
(East Carolina University, 2014)The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and ... -
QUANTITATION OF INTERCELLULAR CONNECTIONS BETWEEN SPERMATOGONIA IN THE MOUSE
(East Carolina University, 2017-05-09)Spermatogonial stem cells (SSCs) are critical in the male reproductive process, as they can either self-renew or proliferate into progenitor cells that differentiate to enter meiosis and eventually form functional sperm. ... -
The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
(East Carolina University, 2009)Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ... -
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
(MDPI, 2021-09-28)The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons. Since perineuronal nets form postnatally, ... -
THE HYALURONAN EXTRACELLULAR MATRIX CRITICALLY REGULATES SYNAPSE FORMATION IN DEVELOPING NEURAL NETWORKS
(East Carolina University, 2021-04-21)The majority of neurodevelopmental disorders present with an imbalance in synaptic signal transmission. The delicate balance of excitatory to inhibitory synaptic transmission is regulated by multiple extracellular and ... -
THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION
(East Carolina University, 2019-07-26)Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying ... -
THE PRO-INFLAMMATORY ROLE OF G-PROTEIN COUPLED RECEPTOR 4 IN AN ACIDIC MICROENVIRONMENT
(East Carolina University, 2018-07-20)The endothelium of the microvascular system serves an ideal mediator between circulating blood and tissues in order to regulate systemic homeostasis. During vascular disease, the normal function and phenotype of endothelial ... -
The Role of Differential Sensitivity to Retinoic Acid (RA) in Regulating Spermatogonial Fate
(East Carolina University, 2018-12-10)In the mammalian testis, the foundation of spermatogenesis is provided by spermatogonial stem cells (SSCs); their progeny either remain as stem cells (following a self-renewal division) or proliferate as undifferentiated ... -
THE ROLE OF RETINOIC ACID IN DIRECTING INITIATION OF SPERMATOGENESIS IN THE MOUSE
(East Carolina University, 2015-10-23)The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization. In the mouse, spermatogenesis ... -
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
(East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ...