Browsing Open Access by Title
Now showing items 199-218 of 866
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Development of improved therapeutic mesothelin-based vaccines for pancreatic cancer
(2018-02-23)Pancreatic cancer is the 5th leading cause of cancer deaths, and there are no effective treatments. We developed a poxvirus platform vaccine with improved immunogenicity and inserted the mesothelin gene to create an ... -
Diabetic muscle infarction: A rare complication of long-standing and poorly controlled diabetes mellitus
(2011-10-09)Objective. To report a case of diabetic muscle infarction (DMI), a rare complication of long-standing poorly controlled diabetes mellitus. Methods. We describe a case of a 45-year-old male with an approximately 8-year ... -
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin α<inf>2</inf>β <inf>1</inf>in mice
(2011)OBJECTIVE: The hypothesis that high-fat (HF) feeding causes skeletal muscle extracellular matrix (ECM) remodeling in C57BL/6J mice and that this remodeling contributes to diet-induced muscle insulin resistance (IR) through ... -
Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)
(2016-08)The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and per- sonal habits, and physical and biological agents that cause ... -
Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome
(2018-09-04)Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS ... -
Differential expression of microRNAs during fiber development between fuzzless- lintless mutant and its wild-type allotetraploid cotton
(2017-01-31)Cotton is one of the most important textile crops but little is known how microRNAs regulate cotton fiber development. Using a well-studied cotton fiberless mutant Xu-142-fl, we compared 54 miRNAs for their expression ... -
Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians
(2016-04-13)Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not ... -
Diffusing an Innovation: Clinician Perceptions of Continuous Predictive Analytics Monitoring in Intensive Care
(2019-03-18)Background The purpose of this article is to describe neonatal intensive care unit clinician perceptions of a continuous predictive analytics technology and how those perceptions influenced clinician adoption. Adopting ... -
Diffusion and perfusion weighted magnetic resonance imaging for tumor volume definition in radiotherapy of brain tumors
(2016-09-21)Accurate target volume delineation is crucial for the radiotherapy of tumors. Diffusion and perfusion magnetic resonance imaging (MRI) can provide functional information about brain tumors, and they are able to detect tumor ... -
Digits lost or gained? Evidence for pedal evolution in the Dwarf salamander complex (Eurycea, Plethodontidae)
(2012-05-23)Change in digit number, particularly digit loss, has occurred repeatedly over the evolutionary history of tetrapods. Although digit loss has been documented among distantly related species of salamanders, it is relatively ... -
Dimeric and tetrameric forms of muscle fructose-1,6- bisphosphatase play different roles in the cell
(2017-12-15)Muscle fructose 1,6-bisphosphatase (FBP2), besides being a regulatory enzyme of glyconeogenesis also protects mitochondria against calcium stress and plays a key role in regulation of the cell cycle, promoting cardiomyocytes ... -
Direct Effects of the Home, School, and Consumer Food Environments on the Association between Food Purchasing Patterns and Dietary Intake among Rural Adolescents in Kentucky and North Carolina, 2017
(2017-10-21)Background: Obesity rates are higher among rural versus urban adolescents. To examine possible mechanisms for the rural-urban adolescent obesity disparity, we examined the direct and indirect effects of food purchasing ... -
Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax
(2011-08-18)Adult T-cell leukemia (ATL) is one of the primary diseases caused by Human T-cell Leukemia Virus type 1 (HTLV-1) infection. The virally-encoded Tax protein is believed to initiate early events in the development of this ... -
Disability Measurement for Korean Community-Dwelling Adults With Stroke: Item-Level Psychometric Analysis of the Korean Longitudinal Study of Ageing
(2018-04-30)Objective: To investigate the psychometric properties of the activities of daily living (ADL) instrument used in the analysis of Korean Longitudinal Study of Ageing (KLoSA) dataset. Methods: A retrospective study was ... -
Disparities in healthy food zoning, farmers' market availability, and fruit and vegetable consumption among North Carolina residents
(2015)Background: Context and purpose of the study. To examine (1) associations between county-level zoning to support farmers’ market placement and county-level farmers’ market availability, rural/urban designation, percent ... -
Disseminated superficial porokeratosis involving the groin and genitalia in a 72-year-old immunocompetent man
(2015-09)The porokeratoses are a group of disorders of abnormal epidermal keratinization resulting in the characteristic histologic feature of the cornoid lamella. Several clinical variants of porokeratosis exist, which are ... -
Distribution and population structure in the naked goby Gobiosoma bosc (Perciformes: Gobiidae) along a salinity gradient in two western Atlantic estuaries Citation metadata
(2018-08-07)Many species of fish produce larvae that undergo a prolonged dispersal phase. However, evidence from a number of recent studies on demersal fishes suggests that the dispersal of propagules may not be strongly correlated ... -
Divergent roles of superoxide and nitric oxide in liver ischemia and reperfusion injury
(2011)Liver ischemia and reperfusion-induced injury is a major clinical complication associated with hemorrhagic or endotoxin shock and thermal injury as well as liver transplantation and resectional surgery. Data obtained from ...