Browsing Open Access by Title
Now showing items 27-46 of 226
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Daily precipitation distributions over the intra-Americas sea and their interannual variability
(2012-05-30)The seasonal (March to October) and interannual variability of the cumulative distribution function (CDF) of precipitation is examined for Meso-America, the eastern Pacific and western Atlantic, commonly referred to as the ... -
Damage control surgery: It's evolution over the last 20 years
(2012-03-15)In less than twenty years, what began as a concept for the treatment of exsanguinating truncal trauma patients has become the primary treatment model for numerous emergent, life threatening surgical conditions incapable ... -
Deep Sequencing Reveals Transcriptome Re-Programming of Taxus × media Cells to the Elicitation with Methyl Jasmonate
(2013-04-30)Background Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel (Taxol®), which is mainly produced in Taxus and has been widely used in cancer chemotherapy. ... -
Digits lost or gained? Evidence for pedal evolution in the Dwarf salamander complex (Eurycea, Plethodontidae)
(2012-05-23)Change in digit number, particularly digit loss, has occurred repeatedly over the evolutionary history of tetrapods. Although digit loss has been documented among distantly related species of salamanders, it is relatively ... -
The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis
(2013-08-30)Blood pressure increases with age, and dysfunction of the dopamine D3 receptor has been implicated in the pathogenesis of hypertension. To evaluate the role of the D3 receptor in aging-related hypertension, we assessed ... -
Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8
(2020-01-24)PUMILIO/FBF (PUF) proteins have a conserved function in stem cell regulation. Caenorhabditis elegans PUF-8 protein inhibits the translation of target mRNAs by interacting with PUF binding element (PBE) in the 30 untranslated ... -
A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
(2013-02)Background Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet ... -
Early cell loss associated with mesenchymal stem cell cardiomyoplasty
(2012-03-01)Background: Human mesenchymal stem cells (hMSCs) show potential for therapeutic cellular cardiomyoplasty. However, a range of delivery methods, including direct intramyocardial injection, have resulted in poor engraftment ... -
The EBM-DPSER Conceptual Model: Integrating Ecosystem Services into the DPSIR Framework
(2013-08)There is a pressing need to integrate biophysical and human dimensions science to better inform holistic ecosystem management supporting the transition from single species or single-sector management to multi-sector ... -
The effect of race and chronic obstructive pulmonary disease on long-term survival after coronary artery bypass grafting
(2013-04)Background: Chronic obstructive pulmonary disease (COPD) is a known predictor of decreased long-term survival after coronary artery bypass grafting (CABG). Differences in survival by race have not been examined. Methods: ... -
Effects of ectopic expression of NGAL on doxorubicin sensitivity
(2012-10-20)Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are ... -
Effects of robotic-assisted laparoscopic prostatectomy on surgical pathology specimens
(2012-03-13)Background Robotic-assisted laparoscopic prostatectomy (RALP) has greatly changed clinical management of prostate cancer. It is important for pathologists and urologists to compare RALP with conventional open radical ... -
Emerging Genomic and Proteomic Evidence on Relationships Among the Animal, Plant and Fungal Kingdoms
(2004-05)Sequence-based molecular phylogenies have provided new models of early eukaryotic evolution. This includes the widely accepted hypothesis that animals are related most closely to fungi, and that the two should be grouped ... -
Engaging in Health Behaviors to Lower Risk for Breast Cancer Recurrence
(2013-01-11)Purpose While post-treatment breast cancer survivors face up to twice the cancer risk of the general population, modifiable health behaviors may somewhat reduce this risk. We sought to better understand health behaviors ... -
Environmental Health Hazardscapes
(2013) -
Environmental Health Resilience
(2013-03-07) -
The errors of individualistic public health interventions: Denial of treatment to obese persons: Comment on “Denial of treatment to obese patients—the wrong policy on personal responsibility for health”
(2013-09-28)I agree entirely with Nir Eyal’s perspective that denying treatment to obese patients is morally wrong. However, the reasons for this belief differ in some ways from Eyal’s analysis. In this commentary, I will try to explain ... -
Establishment of the Coast Range ophiolite microbial observatory (CROMO): Drilling objectives and preliminary outcomes
(2013-11-05)Abstract. This project aimed to establish a subsurface microbial observatory in ultramafic rocks, by drilling into an actively serpentinizing peridotite body, characterizing cored rocks, and outfitting the boreholes for a ...