Browsing Open Access by Issue Date
Now showing items 41-60 of 866
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Paper fish and policy conflict: Catch shares and ecosystem-based management in Maine's groundfishery
(2011)The National Oceanic and Atmospheric Administration professes support for ecosystem-based fisheries management, as mandated by Congress in the Fishery Conservation and Management Act, and as endorsed by the Obama ... -
Single incision laparoscopic ventral hernia repair
(2011)Background and Objectives: Laparoscopic ventral hernia repair (LVH) requires several skin incisions for trocar placement. We have developed a single incision approach to LVH repair. The technique was introduced in clinical ... -
Environmental risk factors for autism
(2011)Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among ... -
Estimating internal consistency using Bayesian methods
(2011)Bayesian internal consistency and its Bayesian credible interval (BCI) are developed and Bayesian internal consistency and its percentile and normal theory based BCIs were investigated in a simulation study. Results indicate ... -
Diversity of the arctic deep-sea benthos
(2011-02-11)A benthic species inventory of 1,125 taxa was compiled from various sources for the central Arctic deeper than 500 m, and bounded to the Atlantic by Fram Strait. The inventory was dominated by arthropods (366 taxa), ... -
Executive summary: "Mantle Frontier" workshop
(2011-03)The workshop on “Reaching the Mantle Frontier: Moho and Beyond” was held at the Broad Branch Road Campus of the Carnegie Institution of Washington on 9–11 September 2010. The workshop attracted seventy-four scientists and ... -
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
(2011-03-11)The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ... -
Importance of glycosylation on function of a potassium channel in neuroblastoma cells
(2011-04)The Kv3.1 glycoprotein, a voltage-gated potassium channel, is expressed throughout the central nervous system. The role of N-glycans attached to the Kv3.1 glycoprotein on conducting and non-conducting functions of the Kv3.1 ... -
Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression
(2011-04-06)Proper coordination of the functions at the DNA replication fork is vital to the normal functioning of a cell. Specifically the precise coordination of helicase and polymerase activity is crucial for efficient passage ... -
Is there a metabolic program in the skeletal muscle of obese individuals?
(2011-04-26)Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are ... -
Replicated shape variation between simple and complex habitats in two estuarine fishes
(2011-05)A replicated pattern of habitat-associated morphology among different lineages may represent adaptive convergence. Deviation from the replicated (shared) pattern of diversification reflects unique (e.g. species specific) ... -
Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program
(2011-05-12)FOG-3, the single Caenorhabditis elegans Tob/BTG protein, directs germ cells to adopt the sperm fate at the expense of oogenesis. Importantly, FOG-3 activity must be maintained for the continued production of sperm that ... -
PP1 forms an active complex with TLRR (lrrc67), a putative PP1 regulatory subunit, during the early stages of spermiogenesis in mice
(2011-06)Mammalian spermatogenesis is a highly regulated developmental pathway that demands dramatic rearrangement of the cytoskeleton of the male germ cell. We have described previously a leucine rich repeat protein, TLRR (also ... -
Coronary artery ligation and intramyocardial injection in a murine model of infarction
(2011-06-07)Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo . With the advent of genetic modifications to the whole organism or the myocardium and an array of biological ... -
Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system
(2011-06-20)Adipocyte infiltration of the musculoskeletal system is well recognized as a hallmark of aging, obesity, and type 2 diabetes. Intermuscular adipocytes might serve as a benign storage site for surplus lipid or play a role ... -
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy
(2011-07-01)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
Evidence for acquisition of virulence effectors in pathogenic chytrids
(2011-07-08)Background The decline in amphibian populations across the world is frequently linked to the infection of the chytrid fungus Batrachochytrium dendrobatidis (Bd). This is particularly perplexing because Bd was only recently ... -
Shoreline change along sheltered coastlines: Insights from the neuse river estuary, NC, USA
(2011-07-12)Coastlines are constantly changing due to both natural and anthropogenic forces, and climate change and associated sea level rise will continue to reshape coasts in the future. Erosion is not only apparent along oceanfront ...