Browsing Open Access by Title
Now showing items 569-588 of 854
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Pain as a global public health priority
(2011-10-06)Background Pain is an enormous problem globally. Estimates suggest that 20% of adults suffer from pain globally and 10% are newly diagnosed with chronic pain each year. Nevertheless, the problem of pain has primarily been ... -
Pain Coping Skills Training for African Americans With Osteoarthritis Study: Baseline Participant Characteristics and Comparison to Prior Studies
(2018-09-19)Background: The Pain Coping Skills Training for African Americans with OsteoaRTthritis (STAART) trial is examining the effectiveness of a culturally enhanced pain coping skills training (CST) program for African Americans ... -
Palmitate-induced ER stress and inhibition of protein synthesis in cultured myotubes does not require Toll-like receptor 4
(2018-01-12)Saturated fatty acids, such as palmitate, are elevated in metabolically dysfunctional condi- tions like type 2 diabetes mellitus. Palmitate has been shown to impair insulin sensitivity and suppress protein synthesis while ... -
Paper fish and policy conflict: Catch shares and ecosystem-based management in Maine's groundfishery
(2011)The National Oceanic and Atmospheric Administration professes support for ecosystem-based fisheries management, as mandated by Congress in the Fishery Conservation and Management Act, and as endorsed by the Obama ... -
Partial cD25 antagonism enables Dominance of antigen-inducible cD25high FOXP3+ regulatory T cells as a Basis for a regulatory T cell- Based adoptive immunotherapy
(2017-12-14)FOXP3+ regulatory T cells (Tregs) represent a promising platform for effective adoptive immunotherapy of chronic inflammatory disease, including autoimmune diseases such as multiple sclerosis. Successful Treg immunotherapy ... -
Pathology Informatics Essentials for Residents: A Flexible Informatics Curriculum Linked to Accreditation Council for Graduate Medical Education Milestones
(2017-01)Context.—Recognition of the importance of informatics to the practice of pathology has surged. Training residents in pathology informatics has been a daunting task for most residency programs in the United States because ... -
Pathology Informatics Essentials for Residents: A Flexible Informatics Curriculum Linked to Accreditation Council for Graduate Medical Education Milestones (a secondary publication)*
(2016-07-11)Context: Recognition of the importance of informatics to the practice of pathology has surged. Training residents in pathology informatics has been a daunting task for most residency programs in the United States because ... -
Patterning of Paternal Investment in Response to Socioecological Change
(2018-10-17)Human paternal investment, and that of many other species, is facultatively expressed and dependent on a diverse array of individual, social, and ecological conditions. Well-documented are the various ways in which men ... -
Patterns of pelvic radiotherapy in patients with stage II/III rectal cancer
(2013-10-02)High-level evidence supports adjuvant radiotherapy for rectal cancer. We examined the influence of sociodemographic factors on patterns of adjuvant radiotherapy for resected Stage II/III rectal cancer. Methods. Patients ... -
The Perceived Availability of Online Social Support: Exploring the Contributions of Illness and Rural Identities in Adults with Chronic Respiratory Illness
(2019-12-29)Joining an online social support group may increase perceived membership to a community, but it does not guarantee that the community will be available when it is needed. This is especially relevant for adults with Chronic ... -
Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle
(2020-04-21)Peroxisomes are essential for lipid metabolism and disruption of liver peroxisomal function results in neonatal death. Little is known about how peroxisomal content and activity respond to changes in the lipid environment ... -
Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression
(2013-04-04)There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone ... -
Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish
(2018-09-24)Recent investigations suggest progestin receptor membrane component 1 (PGRMC1) associates with and transports a wide range of molecules such as heme, cytochromes P450, steroids with 21 carbons, membrane progestin receptor ... -
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
(2019-12-01)PURPOSE: Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the ... -
Phenotypic and Genetic Divergence among Poison Frog Populations in a Mimetic Radiation
(2013-02-06)The evolution of Müllerian mimicry is, paradoxically, associated with high levels of diversity in color and pattern. In a mimetic radiation, different populations of a species evolve to resemble different models, which can ... -
Phosphodiesterases regulate BAY 41-2272-induced VASP phosphorylation in vascular smooth muscle cells
(2012-02-07)BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ...