Browsing Open Access by Author "Zervos, Emmanuel"
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Development of improved therapeutic mesothelin-based vaccines for pancreatic cancer
White, Michael; Freistaedter, Andrew; Jones, Gwendolyn J B; Zervos, Emmanuel; Roper, Rachel L (2018-02-23)Pancreatic cancer is the 5th leading cause of cancer deaths, and there are no effective treatments. We developed a poxvirus platform vaccine with improved immunogenicity and inserted the mesothelin gene to create an ... -
Emerging Role of Immune Checkpoint Blockade in Pancreatic Cancer
Macherla, Shravanti; Laks, Shachar; Naqash, Abdul Rafeh; Bulumulle, Anushi; Zervos, Emmanuel; Muzaffar, Mahvish (2018-11-07)Immune checkpoint blockade (ICB) with programmed cell death protein-1(PD-1)/programmed death ligand -1(PD-L1) antibodies has revolutionized the management of several cancers, especially non-small cell lung cancer, melanoma, ... -
Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer
Zervos, Emmanuel; Agle, Steven C.; Freistaedter, Andrew; Jones, Gwendolyn; Roper, Rachel (2016)Background: Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote tumor development and to be a good target for cancer treatment. Most studies to date have used human mesothelin ... -
Patterns of pelvic radiotherapy in patients with stage II/III rectal cancer
Fitzgerald, Timothy L.; Zervos, Emmanuel; Wong, Jan H. (2013-10-02)High-level evidence supports adjuvant radiotherapy for rectal cancer. We examined the influence of sociodemographic factors on patterns of adjuvant radiotherapy for resected Stage II/III rectal cancer. Methods. Patients ...