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The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi
(2014-05-01)
In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B. burgdorferi must be ...
Root parasitic plant Orobanche aegyptiaca and shoot parasitic plant Cuscuta australis obtained Brassicaceae-specific strictosidine synthase-like genes by horizontal gene transfer
(2014)
Background
Besides gene duplication and de novo gene generation, horizontal gene transfer (HGT) is another important way of acquiring new genes. HGT may endow the recipients with novel phenotypic traits that are important ...
Stair falls: Caregiver's "missed step" as a source of childhood fractures
(2014-01-28)
Background
The purpose of this study was to describe fractures sustained by children and to analyze the associated costs when a caretaker falls down stairs while holding a child.
Materials and methods
Between 2004 and ...
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2014)
Hepatocellular carcinoma (HCC) is characterized by limited response to current
drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability
in a dose- and time-dependent manner, inhibited ...
Advancing research on racial-ethnic health disparities: Improving measurement equivalence in studies with diverse samples
(2014)
To conduct meaningful, epidemiologic research on racial-ethnic health disparities, racial-ethnic samples must be rendered equivalent on other social status and contextual variables via statistical controls of those extraneous ...
Challenges to adaptation: a fundamental concept for the shared socio-economic pathways and beyond
(2014)
The framework for the new scenarios being developed for climate research calls
for the development of a set of Shared Socioeconomic Pathways (SSPs), which are meant to
differ in terms of their challenges to mitigation ...
Brachial Flow-Mediated Dilation and Incident Atrial Fibrillation The Multi-Ethnic Study of Atherosclerosis
(2014)
Objective—It is unknown whether endothelial dysfunction precedes atrial fibrillation (AF) development. The objective of
this study was to examine the association of brachial flow-mediated dilation (FMD) with incident ...
Analysis of the B-RAFV600E mutation in cutaneous melanoma patients with occupational sun exposure
(2014)
Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including ...