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Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome
(2016-05)
Glucocorticoids are the primary therapy for nephrotic syndrome (NS), but have serious side effects and are ineffective in ~20-50% of patients. Thiazolidinediones have recently been suggested to be renoprotective, and to ...
Sclerosing Mesenteritis: A Rare Cause of Small Bowel Obstruction
(2016)
Sclerosing mesenteritis falls within a spectrum of primary idiopathic inflammatory and fibrotic processes that affect the mesentery. The exact etiology has not been determined, although the following associations have been ...
Akhenaten’s Amarna in New Kingdom Egypt: Relations of Landscape and Ideology
(2016-08)
a few years after Pharaoh amenophis iV (ruled ca.1353– 1337 in the Eighteenth dynasty during new Kingdom Egypt) had assumed the highest office in Thebes, he decided to radically reorganize and redirect the Egyptian political ...
Evolutionary Dynamics of Floral Homeotic Transcription Factor Protein–Protein Interactions
(2016-02-22)
Protein–protein interactions (PPIs) have widely acknowledged roles in the regulation of development, but few studies have addressed the timing and mechanism of shifting PPIs over evolutionary history. The B-class MADS-box ...
Essential role of proteasomes in maintaining self-renewal in neural progenitor cells
(2016-01-25)
Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for
cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent ...
Failure patterns and survival outcomes in triple negative breast cancer (TNBC): a 15 year comparison of 448 non-Hispanic black and white women
(2016-06-17)
Purpose: Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer with unique pathologic, molecular and clinical behavior. It occurs more frequently in young blacks and has been reported to have a shorter ...
Blood‐based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)
(2016-09)
Circulating protein markers were assessed in patients with colorectal cancer (CRC) treated with cetuximab in CALGB 80203 to identify prognostic and predictive biomarkers. Patients with locally advanced or metastatic CRC ...
EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy
(2016)
Vici syndrome is a progressive neurodevelopmental multisystem disorder due to recessive mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological, and neuropathological features of 50 children ...
Diffusion and perfusion weighted magnetic resonance imaging for tumor volume definition in radiotherapy of brain tumors
(2016-09-21)
Accurate target volume delineation is crucial for the radiotherapy of tumors. Diffusion and perfusion magnetic resonance imaging (MRI) can provide functional information about brain tumors, and they are able to detect tumor ...
Driving innovation through big open linked data (BOLD): Exploring antecedents using interpretive structural modelling
(2016-07-13)
Innovation is vital to find new solutions to prob- lems, increase quality, and improve profitability. Big open linked data (BOLD) is a fledgling and rapidly evolving field that creates new opportunities for innovation. ...