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Biological significance of RNA-seq and single-cell genomic research in woody plants
(2019-04-01)
RNA-seq and single-cell genomic research emerge as an important research area in the recent years due to its ability to examine genetic information of any number of single cells in all living organisms. The knowledge gained ...
Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion
(2019-06)
Fibrinogen is an essential part of the blood coagulation cascade and a major component of the extracellular matrix in mammals. The interface between fibrinogen and bacterial pathogens is an important determinant of the ...
Hemodynamic-GUIDEd management of Heart Failure (GUIDE-HF)
(2019-04-25)
In that study, incremental reductions in the PA pressures in the monitored arm were associated with both reduction in the frequency of HFH and improvements in health-related quality of life among patients with both preserved ...
Impact of United States political sanctions on international collaborations and research in Iran
(2019-06-17)
International research collaborations improve individual,
institutional and governmental capacities to respond
to health crises and inequalities but may be greatly
affected by political environments. Iran ranks highly
in ...
Alternative splicing of UCP1 by non-cell-autonomous action of PEMT
(2019-11-08)
Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking ...
Health and Occupational Injury Experienced by Latinx Child Farmworkers in North Carolina, USA
(2019-12-30)
Children as young as 10 years old are hired to work on farms in the United States (U.S.).
These children are largely Latinx. Using interview data collected from 202 North Carolina Latinx child
farmworkers in 2017, this ...
Incarcerated uterus and bilateral ovaries in a premature female infant inguinal hernia
(2019-09-28)
We present a case of an inguinal hernia in a premature female infant containing the uterus and bilateral adnexa. This was diagnosed on ultrasound and underwent operative repair. The viable hernia contents were reduced ...
Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
(2019-07-05)
Background
Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believed ...
Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
(2019-03-31)
In rodent skeletal muscle, acyl-coenzyme A (CoA) synthetase 5 (ACSL-5) is suggested to localize to the mitochondria but its precise function in human skeletal muscle is unknown. The purpose of these studies was to define ...
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
(2019-12-01)
PURPOSE:
Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the ...