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Effects of ectopic expression of NGAL on doxorubicin sensitivity
(2012-10-20)
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are ...
Harnessing the PI3K/Akt/mtor pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels
(2012-08-09)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant hematological disorder arising in the thymus from T-cell progenitors. T-ALL mainly affects children and young adults, and remains fatal in 20% of ...
Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer
(2012-05-11)
Background: To evaluate the feasibility of image-guided radiotherapy based on helical Tomotherapy to spare the contralateral parotid gland in head and neck cancer patients with unilateral or no neck node metastases. Methods: ...
Histological and immunohistochemical features of the spleen in persistent polyclonal B-cell lymphocytosis closely mimic splenic B-cell lymphoma
(2012-08-19)
Persistent polyclonal B-cell lymphocytosis (PPBL) is rare and intriguing hematological disorder predominantly reported in young to middle- aged smoking women. It is characterized by persistent moderate polyclonal B-cell ...
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response
(2012-09-20)
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, ...
Landscape influences on fisher success: Adaptation strategies in closed and open access fisheries in southern Chile
(2012-03)
Determinants of fisher success in southern Chile's loco (Concholepas concholepas) fishery are examined by comparing fisher success in exclusive access territories that vary in relationship to tree-plantation development, ...
Nectin like -5 overexpression correlates with the malignant phenotype in cutaneous melanoma
(2012-08-26)
NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant ...
Organic matter characterization and decomposition dynamics in sub-Antarctic streams impacted by invasive beavers
(2012-11)
Despite being a relatively remote and well conserved area, the sub-Antarctic ecoregion faces pressing global threats from climate change, the ozone hole and introduced species. Its freshwater ecosystems are one of the least ...
Prospects for the study of evolution in the deep biosphere
(2012)
Since the days of Darwin, scientists have used the framework of the theory of evolution to explore the interconnectedness of life on Earth and adaptation of organisms to the ever-changing environment. The advent of molecular ...
Mediastinal neoplasms in patients with Graves disease: A possible link between sustained hyperthyroidism and thymic neoplasia'
(2012-07-23)
BACKGROUND: Anterior mediastinal masses are a rare but well documented finding in Graves disease. The vast majority of these lesions represents benign thymic hypertrophy and regress after treatment of the hyperthyroidism. ...