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Some Cardiomyopathy-Causing Troponin I Mutations Stabilize a Functional Intermediate Actin State
(East Carolina University, 2009-03-18)
We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the
distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated ...