Author | Nguyen, Nam Phong | |
Author | Shen, Wei | |
Author | Kratz, Sarah | |
Author | Vock, Jacqueline | |
Author | Vos, Paul | |
Author | Vincent, Vinh-Hung | |
Author | Altdorfer, Gabor | |
Author | Ewell, Lars | |
Author | Jang, Siyoung | |
Author | Karlsson, Ulf | |
Author | Godinez, Juan | |
Author | Mills, Melissa | |
Author | Sroka, Thomas | |
Author | Dutta, Suresh | |
Author | Chi, Alexander | |
Author | The International Geriatric Radiotherapy Group | |
Date Accessioned | 2020-03-31T03:27:35Z | |
Date Available | 2020-03-31T03:27:35Z | |
Date of Issue | 2013-11-26 | |
Identifier (URI) | http://hdl.handle.net/10342/7713 | |
Description | Background: To assess the tolerance of patients with small cell lung cancer undergoing chemoradiation with tomotherapy-based image-guided radiotherapy (IGRT).
Materials and Methods: A retrospective review of the toxicity profile for nine patients with small cell lung cancer of the limited stage who underwent chemoradiation delivered with helical tomotherapy (HT) has been conducted.
Results: Acute grade 3–4 hematologic and esophagitis toxicities developed in two and three patients respectively. One patient developed a pulmonary embolism during radiotherapy. Seven patients had weight loss ranging from 0 to 30 pounds (median: 4 pounds). Three patients had treatment breaks ranging from 2 to 12 days. At a median follow-up of 11 months (range: 2–24 months), no patients developed any radiation related toxicities such as grade 3–4 pneumonitis or other long-term complications. The median survival was estimated to be 15 months. There were two local recurrences, three mediastinal recurrences, and six distant metastases.
Conclusion: Grade 3–4 toxicities remained significant during chemoradiation when radiation was delivered with tomotherapy-based IGRT. However, the absence of grade 3–4 pneumonitis is promising and the use of HT needs to be investigated in future prospective studies. | en_US |
Subject | small cell lung cancer, limited stage, chemoradiation, IGRT | en_US |
Title | Feasibility of tomotherapy-based image-guided radiotherapy for small cell lung cancer | en_US |
Type | Article | en_US |
Identifier (DOI) | 10.3389/fonc.2013.00289 | |
Journal Name | Frontiers in Oncology | en_US |
Journal Volume | 3 | en_US |
Journal Issue | 289 | en_US |
Article Pages | 1-4 | en_US |