Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes

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Author
Puett, Robin C.; Yanosky, Jeff D.; Mittleman, Murray A.; Montresor-Lopez, Jessica; Bell, Ronny A.; Crume, Tessa L.; Dabelea, Dana; Dolan, Lawrence M.; D'Agostino, Ralph B. Jr.; Marcovina, Santica M.; Pihoker, Catherine; Reynolds, Kristi; Urbina, Elaine; Liese, Angela D.
Abstract
Background: Evidence remains equivocal regarding the association of inflammation, a precursor to cardiovascular disease, and acute exposures to ambient air pollution from traffic-related particulate matter. Though youth with type 1 diabetes are at higher risk for cardiovascular disease, the relationship of inflammation and ambient air pollution exposures in this population has received little attention. Objectives: Using five geographically diverse US sites from the racially- and ethnically-diverse SEARCH for Diabetes in Youth Cohort, we examined the relationship of acute exposures to PM2.5 mass, Atmospheric Dispersion Modeling System (ADMS)-Roads traffic-related PM concentrations near roadways, and elemental carbon (EC) with biomarkers of inflammation including interleukin-6 (IL-6), c-reactive protein (hs-CRP) and fibrinogen. Methods: Baseline questionnaires and blood were obtained at a study visit. Using a spatio-temporal modeling approach, pollutant exposures for 7 days prior to blood draw were assigned to residential addresses. Linear mixed models for each outcome and exposure were adjusted for demographic and lifestyle factors identified a priori. Results: Among the 2566 participants with complete data, fully-adjusted models showed positive associations of EC average week exposures with IL-6 and hs-CRP, and PM2.5 mass exposures on lag day 3 with IL-6 levels. Comparing the 25th and 75th percentiles of average week EC exposures resulted in 8.3% higher IL-6 (95%CI: 2.7%,14.3%) and 9.8% higher hs-CRP (95%CI: 2.4%,17.7%). We observed some evidence of effect modification for the relationships of PM2.5 mass exposures with hs-CRP by gender and with IL-6 by race/ethnicity. Conclusions: Indicators of inflammation were associated with estimated traffic-related air pollutant exposures in this study population of youth with type 1 diabetes. Thus youth with type 1 diabetes may be at increased risk of air pollution-related inflammation. These findings and the racial/ethnic and gender differences observed deserve further exploration.
URI
http://hdl.handle.net/10342/8126
Subject
Traffic-related air pollution; Inflammation; Diabetes
Date
2019-08-13
Citation:
APA:
Puett, Robin C., & Yanosky, Jeff D., & Mittleman, Murray A., & Montresor-Lopez, Jessica, & Bell, Ronny A., & Crume, Tessa L., & Dabelea, Dana, & Dolan, Lawrence M., & D'Agostino, Ralph B. Jr., & Marcovina, Santica M., & Pihoker, Catherine, & Reynolds, Kristi, & Urbina, Elaine, & Liese, Angela D.. (August 2019). Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes. , (), - . Retrieved from http://hdl.handle.net/10342/8126

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MLA:
Puett, Robin C., and Yanosky, Jeff D., and Mittleman, Murray A., and Montresor-Lopez, Jessica, and Bell, Ronny A., and Crume, Tessa L., and Dabelea, Dana, and Dolan, Lawrence M., and D'Agostino, Ralph B. Jr., and Marcovina, Santica M., and Pihoker, Catherine, and Reynolds, Kristi, and Urbina, Elaine, and Liese, Angela D.. "Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes". . . (), August 2019. September 27, 2023. http://hdl.handle.net/10342/8126.
Chicago:
Puett, Robin C. and Yanosky, Jeff D. and Mittleman, Murray A. and Montresor-Lopez, Jessica and Bell, Ronny A. and Crume, Tessa L. and Dabelea, Dana and Dolan, Lawrence M. and D'Agostino, Ralph B. Jr. and Marcovina, Santica M. and Pihoker, Catherine and Reynolds, Kristi and Urbina, Elaine and Liese, Angela D., "Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes," , no. (August 2019), http://hdl.handle.net/10342/8126 (accessed September 27, 2023).
AMA:
Puett, Robin C., Yanosky, Jeff D., Mittleman, Murray A., Montresor-Lopez, Jessica, Bell, Ronny A., Crume, Tessa L., Dabelea, Dana, Dolan, Lawrence M., D'Agostino, Ralph B. Jr., Marcovina, Santica M., Pihoker, Catherine, Reynolds, Kristi, Urbina, Elaine, Liese, Angela D.. Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes. . August 2019; (): . http://hdl.handle.net/10342/8126. Accessed September 27, 2023.
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