Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
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Date
2015
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Authors
Calvin, Justin R.
Sanderlin, Edward J.
Yang, Li V.
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Abstract
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation,
for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis,
referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies
further demonstrate that both genetic factors such as oncogenes and tumor suppressors and
microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic
metabolism of cancer cells. Reciprocally, altered cancer cell metabolism can modulate the
tumor microenvironment which plays important roles in cancer cell somatic evolution,
metastasis, and therapeutic response. In this article, we review the progression of current
understandings on the molecular interaction between cancer cell metabolism and the tumor
microenvironment. In addition, we discuss the implications of these interactions in cancer
therapy and chemopreventio
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DOI
10.3390/ijms160511055