Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

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McCubrey, James A.; Fitzgerald, Timothy L.; Yang, Li V.; Lertpiriyapong, Kvin; Steelman, Linda S.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Neri, Luca M.; Cocco, Lucio; Martelli, Alberto M.; Laidler, Piotr; Dulińska-Litewka, Joanna; Rakus, Dariusz; Gizak, Agnieszka; Nicoletti, Ferdinando; Falzone, Luca; Candido, Saverio; Libra, Massimo
Abstract
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 pathways elicit essential regulatory influences on cancer initiation, EMT and progression. A common kinase involved in all these pathways is moon-lighting kinase glycogen synthase kinase-3 (GSK-3). These pathways are also regulated by micro-RNAs (miRs). TP53 and components of these pathways can regulate the expression of miRs. Targeting members of these pathways may improve cancer therapy in those malignancies that display their abnormal regulation. This review will discuss the interactions of the multi-functional GSK-3 enzyme in the Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, Hh, Notch and TP53 pathways. The regulation of these pathways by miRs and their effects on CSC generation, EMT, invasion and metastasis will be discussed.
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http://hdl.handle.net/10342/8388
Date
2017-02
Citation:
APA:
McCubrey, James A., & Fitzgerald, Timothy L., & Yang, Li V., & Lertpiriyapong, Kvin, & Steelman, Linda S., & Abrams, Stephen L., & Montalto, Giuseppe, & Cervello, Melchiorre, & Neri, Luca M., & Cocco, Lucio, & Martelli, Alberto M., & Laidler, Piotr, & Dulińska-Litewka, Joanna, & Rakus, Dariusz, & Gizak, Agnieszka, & Nicoletti, Ferdinando, & Falzone, Luca, & Candido, Saverio, & Libra, Massimo. (February 2017). Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells. Oncotarget, (8:8), p.14221-14250. Retrieved from http://hdl.handle.net/10342/8388

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MLA:
McCubrey, James A., and Fitzgerald, Timothy L., and Yang, Li V., and Lertpiriyapong, Kvin, and Steelman, Linda S., and Abrams, Stephen L., and Montalto, Giuseppe, and Cervello, Melchiorre, and Neri, Luca M., and Cocco, Lucio, and Martelli, Alberto M., and Laidler, Piotr, and Dulińska-Litewka, Joanna, and Rakus, Dariusz, and Gizak, Agnieszka, and Nicoletti, Ferdinando, and Falzone, Luca, and Candido, Saverio, and Libra, Massimo. "Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells". Oncotarget. 8:8. (14221-14250.), February 2017. December 01, 2020. http://hdl.handle.net/10342/8388.
Chicago:
McCubrey, James A. and Fitzgerald, Timothy L. and Yang, Li V. and Lertpiriyapong, Kvin and Steelman, Linda S. and Abrams, Stephen L. and Montalto, Giuseppe and Cervello, Melchiorre and Neri, Luca M. and Cocco, Lucio and Martelli, Alberto M. and Laidler, Piotr and Dulińska-Litewka, Joanna and Rakus, Dariusz and Gizak, Agnieszka and Nicoletti, Ferdinando and Falzone, Luca and Candido, Saverio and Libra, Massimo, "Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells," Oncotarget 8, no. 8 (February 2017), http://hdl.handle.net/10342/8388 (accessed December 01, 2020).
AMA:
McCubrey, James A., Fitzgerald, Timothy L., Yang, Li V., Lertpiriyapong, Kvin, Steelman, Linda S., Abrams, Stephen L., Montalto, Giuseppe, Cervello, Melchiorre, Neri, Luca M., Cocco, Lucio, Martelli, Alberto M., Laidler, Piotr, Dulińska-Litewka, Joanna, Rakus, Dariusz, Gizak, Agnieszka, Nicoletti, Ferdinando, Falzone, Luca, Candido, Saverio, Libra, Massimo. Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells. Oncotarget. February 2017; 8(8) 14221-14250. http://hdl.handle.net/10342/8388. Accessed December 01, 2020.
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