Effects of aerobic training with and without weight loss on insulin sensitivity and lipids
Author
Swift, Damon L.; Houmard, Joseph A.; Slentz, Cris A.; Kraus, William E.
Abstract
Purpose:
The purpose of this study is to evaluate the effect of exercise training with modest or greater weight loss (≥3%) or not (<3%) on insulin sensitivity, lipoprotein concentrations, and lipoprotein particle size in overweight and obese participants.
Methods:
Adults (N = 163, body mass index: 25–37 [kg/m2]) participated in 8 months of exercise training. Insulin sensitivity, lipid concentrations, lipid particle size and other cardiometabolic variables were measured at baseline and follow-up. Participants were categorized by whether they achieved at least modest weight loss (≥ 3%) or not (<3%) following the intervention.
Results:
A greater improvement in insulin sensitivity was observed in adults performing exercise training with at least modest weight loss (2.2 mU·l-1 ·min -1, CI: 1.5 to 2.8) compared to those who did not (0.8 mU·l-1 ·min -1, CI: 0.5 to 1.2). Similar results were observed for acute insulin response, triglycerides, non-HDL cholesterol concentration, low density lipoprotein (LDL) particle size and high density lipoprotein (HDL) particle size (p<0.05), when all exercise groups were combined. No significant results across weight loss categories were observed for LDL, HDL, glucose, or insulin levels.
Conclusion:
The present study suggests that aerobic exercise combined with at least modest weight loss leads to greater improvements in insulin sensitivity, triglycerides as well as other non-traditional lipid risk factors (non-HDL cholesterol, HDL/LDL particle size). Clinicians should advocate patients who are overweight/obese to exercise and obtain modest weight loss for improved cardiovascular benefits.
Date
2018-05-18
Citation:
APA:
Swift, Damon L., & Houmard, Joseph A., & Slentz, Cris A., & Kraus, William E.. (May 2018).
Effects of aerobic training with and without weight loss on insulin sensitivity and lipids.
,
(),
-
. Retrieved from
http://hdl.handle.net/10342/8508
MLA:
Swift, Damon L., and Houmard, Joseph A., and Slentz, Cris A., and Kraus, William E..
"Effects of aerobic training with and without weight loss on insulin sensitivity and lipids". .
. (),
May 2018.
September 22, 2023.
http://hdl.handle.net/10342/8508.
Chicago:
Swift, Damon L. and Houmard, Joseph A. and Slentz, Cris A. and Kraus, William E.,
"Effects of aerobic training with and without weight loss on insulin sensitivity and lipids," , no.
(May 2018),
http://hdl.handle.net/10342/8508 (accessed
September 22, 2023).
AMA:
Swift, Damon L., Houmard, Joseph A., Slentz, Cris A., Kraus, William E..
Effects of aerobic training with and without weight loss on insulin sensitivity and lipids. .
May 2018;
():
.
http://hdl.handle.net/10342/8508. Accessed
September 22, 2023.
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