Browsing Pharmacology and Toxicology by Title
Now showing items 30-49 of 114
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E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin
(East Carolina University, 2008-12-12)δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins. Here, we describe distinctive features of δ-catenin localization and its association with E-cadherin in HEK293 epithelial cells. In HEK293 cells ... -
EARLY LIFE STRESS AND PHARMACEUTICAL POLLUTANTS: DEVELOPMENTAL TOXICITY OF EMERGING AQUATIC CONTAMINANTS IN A MODEL TERRESTRIAL SPECIES
(East Carolina University, 2019-07-18)Trace amounts of pharmaceutical and personal care products are plaguing water sources around the globe, and with no current regulations, these emerging contaminants pose a threat to environmental and human health. While ... -
EFFECTS OF CANNABIDIOL ON VOCAL LEARNING AND RECOVERY FROM CNS DAMAGE
(East Carolina University, 2019-06-19)Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and was recently effective for the treatment of childhood seizures caused by Dravet and ... -
Effects of psychological stressors and [delta]⁹-THC acutely and chronically on zebra finch song behavior and dendritic spine density
(East Carolina University, 2020-06-22)This dissertation investigated song performance and dendritic spine density, following acute restraint stress in adult zebra finches and, following chronic mild stress and CB1 receptor partial agonist [delta]⁹-tetrahydrocannabinol ... -
Environmental risk factors for autism
(2010-04)Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
Examining the therapeutic potential of the investigational agent, 15dPMJ2, in mismatch repair proficient colon cancer
(East Carolina University, 2022-08-15)Despite the success of immune checkpoint inhibitor (ICI) therapy in many cancers, colon cancer with low microsatellite instability (MSI-L), also known as proficient mismatch repair (pMMR), does not respond to these agents. ... -
EXPLORING DIFFERENCES IN INDIVIDUAL SUSCEPTIBILITY TO LIPOTOXICITY AND THE UNDERLYING MECHANISMS IN THE MITOCHONDRIA OF PRIMARY PREADIPOCYTES
(East Carolina University, 2018-07-17)Prolonged exposure to fatty acids (FAs), at levels normally seen during fasting, can be cytotoxic in vulnerable cells including preadipocytes. Prior work from our laboratory has shown that FAs cause mitochondrial inner ... -
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
(5/16/2016)Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ... -
Health effects following subacute exposure to geogenic dust collected from active drainage surfaces (Nellis Dunes Recreation Area, Las Vegas, NV)
(2017-12-08)The specific health effects of directinhalation of fine minerogenic dusts generated by natural soil surfaces remain poorly known and relatively little researched. To learn more about this exposure and its contribution to ... -
Hyaluronan Oligosaccharides Inhibit Tumorigenicity of Osteosarcoma Cell Lines MG-63 and LM-8 in Vitro and in Vivo via Perturbation of Hyaluronan-Rich Pericellular Matrix of the Cells
(East Carolina University, 2007-07)Numerous studies have demonstrated a correlation between hyaluronan expression and the malignant properties of various kinds of cancer , and inhibition of hyaluronan production causes decreased tumor growth. Hyaluronan ...