Browsing Pharmacology and Toxicology by Author "Pharmacology and Toxicology"
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OPPOSING PERSISTENT BEHAVIORAL EFFECTS OF PHYTO- AND ENDOCANNABINOIDS FOLLOWING CHRONIC DEVELOPMENTAL, BUT NOT ADULT, TREATMENTS
Aldhafiri, Ahmed Jaleel (East Carolina University, 2019-04-23)The rate of adolescent Cannabis abuse is increasing for recreational purposes and it is thought to be linked to a range of developmental and social problems. Many studies have demonstrated effects of early Cannabis exposure ... -
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
Jiang, Qixiao (East Carolina University, 2013)Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ... -
Prohibitin: A novel regulator of inflammatory cell dynamics
Psaltis, Christine E (East Carolina University, 2020-02-04)Inflammation is a complex mechanism primarily driven by the immune system to eradicate pathogens/foreign substances and restore tissue homeostasis. Despite the beneficial effects that inflammation employs, signaling can ... -
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
Penumarti, Anusha (East Carolina University, 2014)The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
Nagchowdhuri, Partha S. (East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
SYNTHESIS AND MOLECULAR EVALUATION OF 15-DEOXY-Δ12,14-PROSTAMIDE J2 AS A NOVEL ANTI-SKIN CANCER AGENT
Ladin, Daniel A (East Carolina University, 2017-08-16)Skin cancers including non-melanoma skin cancer (NMSC) and melanoma are the most common form of cancer in the United States and thus represent a substantial burden to the health care system. Current chemotherapeutic ...