Browsing Pharmacology and Toxicology by Submit Date
Now showing items 41-60 of 81
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Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereof
(1996-06-18)A method of combatting cancer in a subject comprising administering to said subject dehydroepiandrosterone (DHEA) or an analog thereof in an amount effective to combat cancer is disclosed in which heart failure induced by ... -
Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpression
(2000-10-24)An agent of the chemical formula C.sub.7 N.sub.3 H.sub.8 O.sub.2 R.sup.1 R.sup.2 XX.sup.1, wherein X and X.sup.1 are each independently C or N but not simultaneously, R.sup.1 is lower alkyl, alkenyl or alkynyl, halogen or ... -
Satiety inducing composition comprising Neuropeptide Y analogues and methods of inducing satiety and treating a disease or condition associated with it
(2002-07-30)Satiety inducing composition comprises Neuropeptide Y analogues which are effective for inducing satiety and for treating diseases and conditions associated with a lacking of, or having lowered, satiety. -
Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
(2002-08-13)A composition, device, kit and method for countering or diagnosing cytidine deaminase or deoxycytidine deaminase over-expression or a disorder associated with it, or an increase in number or toxicity of pro-inflammatory ... -
Method of treating adenosine depletion
(1997-08-26)A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective ... -
Method for reducing adenosine levels with a dehydroepiandrosterone and optionally a ubiquinone
(2000-07-11)A method and composition for reducing adenosine levels comprises administering a dehydroepiandrosterone, and optionally a ubiquinone. -
Neuropeptide Y analogues, compositions and methods of lowering blood pressure
(2000-06-13)Neuropeptide Y analogues, and their compositions are effective for lower blood pressure. -
Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
(2000-03-21)A DNA comprises an oligonucleotide antisense to mRNA encoding an adenosine A.sub.1 or A.sub.3 receptor. The oligo is provided as a composition, various formulations, a capsule, and cartridge and in the form of a kit. The ... -
Composition, kit and method for treatment of disorders associated withbronchoconstriction and lung inflammation
(2000-02-15)A method of reducing bronchoconstriction in a subject in need of suchtreatment is disclosed. The method comprises administering to the subject an Antisenseoligonucleotide molecule directed against the A.sub.1 or A.sub.3 ... -
Molecular mechanism of anandamide-induced apoptosis in non-melanoma skin cancer.
(East Carolina University, 2015)Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selective toxicity is the major problem associated with chemotherapeutic and radiation therapy for NMSCs. The goal of the present ... -
The immune and neurological impacts of developmental Bisphenol A exposure in a C57bl/6 mouse model
(East Carolina University, 2014)Environmental exposure to exogenous agents during critical time points of development may be associated with the onset of deleterious effects, including immune and neurological disorders. Numerous studies have shown that ... -
Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ... -
Discovery and investigation of a novel role for mitochondrial prohibitin in mitigating acute heart failure in endotoxic shock
(East Carolina University, 2014)Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the United States (US). In spite of significant advances in medical care the mortality rate for sepsis has continued to rise. ... -
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
(East Carolina University, 2013)Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ... -
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
(East Carolina University, 2013)Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ... -
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
(East Carolina University, 2012)The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ... -
Molecular Mechanisms of Peripheral N-Methyl-D-Aspartate Mediated Pressor Response
(East Carolina University, 2012)The primary goal of this study was to characterize the N-Methyl-D-Aspartate (NMDA) receptor within the cardiovascular system and elucidate the molecular mechanisms involved in peripheral NMDA receptor-mediated pressor ... -
Mast cells and the IL-33/ST2 axis are essential determinants of carbon nanotube toxicity
(East Carolina University, 2012)The rise of nanomaterial use in a variety of applications, including biomedical imaging and drug delivery, has led to concern about the potentially hazardous impacts on human health. Mast cells are critical for innate and ... -
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
(East Carolina University, 2009-01)Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ...