Repository logo
 

Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas

Loading...
Thumbnail Image

Date

2015-09

Access

Authors

Elhammali, Adnan
Patel, Mukund
Weinberg, Benjamin
Verma, Vivek
Liu, Jingxia
Olsen, Jeffrey R.
Gay, Hiram A.

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Background To consolidate literature reports of serious late gastrointestinal toxicities after hypofractionated radiation treatment of pancreatic cancer and attempt to derive normal tissue complication probability (NTCP) parameters using the Lyman-Kutcher-Burman model. Methods Published reports of late grade 3 or greater gastrointestinal toxicity after hypofractionated treatment of pancreatic cancer were reviewed. The biologically equivalent dose in 1.8 Gy fractions was calculated using the EQD model. NTCP parameters were calculated using the LKB model assuming 1–5 % of the normal tissue volume was exposed to the prescription dose with α/β ratios of 3 or 4. Results A total of 16 human studies were examined encompassing a total of 1160 patients. Toxicities consisted of ulcers, hemorrhages, obstructions, strictures, and perforations. Non-hemorrhagic and non-perforated ulcers occurred at a rate of 9.1 % and were the most commonly reported toxicity. Derived NTCP parameter ranges were as follows: n = 0.38–0.63, m = 0.48–0.49, and TD50 = 35–95 Gy. Regression analysis showed that among various study characteristics, dose was the only significant predictor of toxicity. Conclusions Published gastrointestinal toxicity reports after hypofractionated radiotherapy for pancreatic cancer were compiled. Median dose was predictive of late grade ≥ 3 gastrointestinal toxicity. Preliminary NTCP parameters were derived for multiple volume constraints.

Description

Keywords

Citation

Radiation Oncology (London, England); 10:186 p. 1-8

DOI

10.1186/s13014-015-0489-2

Collections