Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review

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dc.contributor.authorQuinn, Joseph W.
dc.contributor.authorSewell, Kerry
dc.contributor.authorSimmons, Dell E.
dc.date.accessioned2018-07-02T16:16:03Z
dc.date.available2018-07-02T16:16:03Z
dc.date.issued2018-03-21
dc.description.abstractBackground: Healthcare-acquired hypernatremia (serum sodium >145 mEq/dL) is common among critically ill and other hospitalized patients and is usually treated with hypotonic fluid and/or diuretics to correct a “free water deficit.” However, many hypernatremic patients are eu- or hypervolemic, and an evolving body of literature emphasizes the importance of rapidly returning critically ill patients to a neutral fluid balance after resuscitation. Objective: We searched for any randomized- or observational-controlled studies evaluating the impact of active interventions intended to correct hypernatremia to eunatremia on any outcome in volume-resuscitated patients with shock and/or sepsis. Data sources: We performed a systematic literature search with studies identified by searching MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, ClinicalTrials.gov, IndexCatalogue of the Library of the Surgeon General’s Office, DARE (Database of Reviews of Effects), and CINAHL and scanning reference lists of relevant articles with abstracts published in English. Data synthesis: We found no randomized- or observational-controlled trials measuring the impact of active correction of hypernatremia on any outcome in resuscitated patients. Conclusion: Recommendations for active correction of hypernatremia in resuscitated patients with sepsis or shock are unsupported by clinical research acceptable by modern evidence standards.en_US
dc.description.sponsorshipECU Open Access Publishing Support Funden_US
dc.identifier.doihttps://doi.org/10.1177/2050312118762043
dc.identifier.urihttp://hdl.handle.net/10342/6814
dc.language.isoen_USen_US
dc.relation.urihttp://journals.sagepub.com/doi/full/10.1177/2050312118762043en_US
dc.subjectHypernatremiaen_US
dc.subjectSodiumen_US
dc.subjectFluid therapyen_US
dc.subjectWater-electrolyte imbalancesen_US
dc.subjectCritical illnessen_US
dc.subjectShocken_US
dc.titleRecommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic reviewen_US
dc.typeArticleen_US
ecu.journal.nameSage Open Medicineen_US
ecu.journal.pages1-6en_US
ecu.journal.volume6en_US

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