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The Potential Role of Magnetic Resonance Spectroscopy in Image-Guided Radiotherapy

dc.contributor.authorNguyen, Mai Lin
dc.contributor.authorWillows, Brooke
dc.contributor.authorKhan, Rihan
dc.contributor.authorChi, Alexander
dc.contributor.authorKim, Lyndon
dc.contributor.authorNour, Sherif G.
dc.contributor.authorSroka, Thomas
dc.contributor.authorKerr, Christine
dc.contributor.authorGodinez, Juan
dc.contributor.authorMills, Melissa
dc.contributor.authorKarlsson, Ulf
dc.contributor.authorAltdorfer, Gabor
dc.contributor.authorNguyen, Nam P.
dc.contributor.authorJendrasiak, Gordon
dc.date.accessioned2016-06-23T17:14:05Z
dc.date.available2016-06-23T17:14:05Z
dc.date.issued2014-05
dc.description.abstractMagnetic resonance spectroscopy (MRS) is a non-invasive technique to detect metabolites within the normal and tumoral tissues. The ability of MRS to diagnose areas of high metabolic activity linked to tumor cell proliferation is particularly useful for radiotherapy treatment planning because of better gross tumor volume (GTV) delineation. The GTV may be targeted with higher radiation dose, potentially improving local control without excessive irradiation to the normal adjacent tissues. Prostate cancer and glioblastoma multiforme (GBM) are two tumor models that are associated with a heterogeneous tumor distribution. Preliminary studies suggest that the integration of MRS into radiotherapy planning for these tumors is feasible and safe. Image-guided radiotherapy (IGRT) by virtue of daily tumor imaging and steep dose gradient may allow for tumor dose escalation with the simultaneous integrated boost technique (SIB) and potentially decrease the complications rates in patients with GBM and prostate cancers.en_US
dc.identifier.citationFrontiers in Oncology; 4: p. 1-6en_US
dc.identifier.doi10.3389/fonc.2014.00091
dc.identifier.issn2234-943X
dc.identifier.pmidpmc4017160en_US
dc.identifier.urihttp://hdl.handle.net/10342/5733
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017160/en_US
dc.subjectMRSen_US
dc.subjectIGRTen_US
dc.subjectprostate canceren_US
dc.subjectGBMen_US
dc.titleThe Potential Role of Magnetic Resonance Spectroscopy in Image-Guided Radiotherapyen_US
dc.typeArticleen_US
ecu.journal.nameFrontiers in Oncologyen_US
ecu.journal.pages1-6en_US
ecu.journal.volume4en_US

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